Article Figures & Data
Figures
- FIGURE 1.
MBF in DCM/AF, DCM/SR, and controls as measured by H215O PET at baseline and under adenosine infusion (ADO). MBF at baseline has been corrected for rate–pressure product.
- FIGURE 2.
Coronary flow reserve (CFR) calculated from MBF under adenosine infusion divided by baseline MBF corrected for rate–pressor product in DCM/AF, DCM/SR, and controls as determined by H215O PET.
- FIGURE 3.
CVR at baseline and under adenosine administration (ADO) in DCM/AF, DCM/SR, and controls.
Tables
DCM/AF patients DCM/SR patients Control subjects Parameter Mean ± SD n Mean ± SD n Mean ± SD n Age (y) 55 ± 12 12 43 ± 15 18 47 ± 13 22 AF duration (mo) 32 ± 39 9 — — — — NYHA class 2.4 ± 0.5 10 2.1 ± 1.1 17 1 22 Risk factors (%) Hypertension 42 12 22 18 41 22 Diabetes mellitus 33 12 22 18 0 22 Smoking 42 12 33 18 27 22 Family history 17 12 39 18 18 22 Hypercholesterolemia 58 12 29 17 45 22 Obesity 58 12 22 18 23 22 Framingham risk score 13 ± 7 12 8 ± 8 15 9 ± 8 19 Medication Amiodarone 42* 12 6 18 0 22 ACE inhibitor/AT1 antagonist 100*† 12 89† 18 9 22 β-receptor antagonist 92*† 12 61 18 32 22 Calcium antagonist 0 12 6 18 5 22 Digitalis 92* 12 22 18 0 22 Parameter DCM/AF patients DCM/SR patients Controls n 12 18 22 LA (cm) 5.4 ± 1.0*† 4.0 ± 1.2 3.9 ± 0.5 LV EDD (cm) 6.5 ± 1.0 6.3 ± 0.8 5.4 ± 0.8 LV ESD (cm) 4.5 ± 1.2* 4.7 ± 0.8* 3.3 ± 0.5 PW (cm) 1.2 ± 0.2* 1.0 ± 0.1 1.1 ± 0.1 IVS (cm) 1.2 ± 0.2 0.9 ± 0.1* 1.2 ± 0.2 FS (%) 25.2 ± 10.8* 24.3 ± 5.2* 39.1 ± 5.6 LV EF (%) 36.7 ± 12.4* 31.7 ± 14.4* 66.9 ± 5.6 ↵* P < 0.05 vs. controls.
↵† P < 0.05 vs. DCM/SR patients.
LA and LV = left atrial and left ventricular diameters, respectively; EDD and ESD = end-diastolic and end-systolic diameters, respectively; PW and IVS = posterior wall and interventricular septum thicknesses, respectively; FS = fractional shortening; EF = ejection fraction.
Baseline Adenosine Parameter DCM/AF DCM/SR Controls DCM/AF DCM/SR Controls n 12 18 22 10 14 22 SBP 131 ± 25* 110 ± 16 125 ± 18 128 ± 20 116 ± 13 130 ± 16 DBP 75 ± 10 68 ± 12 76 ± 8 72 ± 12 66 ± 13 73 ± 9 MAP 94 ± 13* 82 ± 12 92 ± 11 91 ± 13 83 ± 12 92 ± 10 HR 66 ± 11 68 ± 8 62 ± 8 67 ± 14† 78 ± 15 91 ± 14 RPP 8,520 ± 1,865 7,476 ± 1,307 7,801 ± 1,743 8,552 ± 2,165† 9,056 ± 2,221 11,924 ± 2,336 MBF-RPP septal MBF-RPP anterior MBF-RPP lateral MBF-RPP inferior n Controls Baseline 1.23 ± 0.50 1.11 ± 0.19 1.19 ± 0.28 1.03 ± 0.25 22 Adenosine 3.68 ± 1.19 3.35 ± 0.85 3.57 ± 1.05 3.68 ± 1.17 22 DCM/SR Baseline 1.07 ± 0.37 1.09 ± 0.33 1.30 ± 0.44 1.14 ± 0.38 18 Adenosine 2.75 ± 1.72 2.37 ± 1.11 2.49 ± 1.45 2.65 ± 1.39 14 DCM/AF Baseline 0.76 ± 0.33 0.84 ± 0.25 0.96 ± 0.45 0.73 ± 0.33 12 Adenosine 1.17 ± 0.65 1.48 ± 0.97 1.58 ± 1.21 1.24 ± 0.96 10 MBF-RPP = MBF corrected for RPP.
All values are expressed as mean ± SD.
