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Effect of Patient Morphology on Dosimetric Calculations for Internal Irradiation as Assessed by Comparisons of Monte Carlo Versus Conventional Methodologies

Antigoni Divoli, Sophie Chiavassa, Ludovic Ferrer, Jacques Barbet, Glenn D Flux and Manuel Bardiès
Journal of Nuclear Medicine February 2009, 50 (2) 316-323; DOI: https://doi.org/10.2967/jnumed.108.056705

Article Figures & Data

Figures

Tables

  • TABLE 1

    Details of 9 Patients and Mathematic Phantom ORNL

    Age (y)Weight (kg)Height (m)Organ mass (g)
    SubjectLungsSpleenKidneysLiver
    ORNLNA701.741,0001832991,910
     P145681.751,5404656112,408
     P254901.751,8154386973,104
     P352631.761,6007745301,809
     P466661.631,2261454211,319
     P576901.621,0804425281,707
     P657611.627552615961659
     P741701.801,2303507132,685
     P843871.7810672147462361
     P938591.801,5201805642,700
    Mean*52.472.71.721,314.8363.2600.72,194.7
     SD*12.512.70.1329.6195.3104.3595.4

    • ↵* Mean and SD values exclude ORNL phantom.

    • NA = not applicable.

  • TABLE 2

    Cumulated Activity Concentrations

    Activity concentration (MBq·s·mL−1)
    AreaA*BCDEF
    Lungs2.01 × 1044.02 × 1048.04 × 1041.61 × 1053.22 × 1056.43 × 105
    Kidneys5.92 × 1045.92 × 1045.92 × 1045.92 × 1045.92 × 1045.92 × 104
    Liver4.20 × 1044.20 × 1044.20 × 1044.20 × 1044.20 × 1044.20 × 104
    Spleen1.26 × 1051.26 × 1051.26 × 1051.26 × 1051.26 × 1051.26 × 105
    Tumor in liver3.09 × 1056.19 × 1051.24 × 1062.48 × 1064.95 × 1069.90 × 106
    Tumor in lung3.34 × 1053.34 × 1053.34 × 1053.34 × 1053.34 × 1053.34 × 105

    • ↵* Distribution A was derived from Rizzieri et al. (24).

  • TABLE 3

    OLINDA/EXM and Patient-Specific 131I S Factors (mGy·MBq−1·s−1) Calculated with MCNPX2.5.0 for Patient P1

    Source
    TargetLungsSpleenKidneysLiverTumor in lungTumor in liver
    Lungs
     OLINDA/EXM2.19 × 10−54.55 × 10−71.97 × 10−75.49 × 10−7NANA
     OEDIPE2.14 × 10−57.26 × 10−71.68 × 10−76.00 × 10−72.28 × 10−72.88 × 10−6
     Ratio1.020.631.170.92NANA
    Spleen
     OLINDA/EXM4.54 × 10−78.09 × 10−51.87 × 10−62.16 × 10−7NANA
     OEDIPE7.29 × 10−77.93 × 10−51.30 × 10−63.84 × 10−72.30 × 10−72.65 × 10−6
     Ratio0.621.021.440.56NANA
    Kidneys
     OLINDA/EXM1.97 × 10−71.87 × 10−65.99 × 10−58.19 × 10−7NANA
     OEDIPE1.72 × 10−71.30 × 10−65.91 × 10−59.07 × 10−72.22 × 10−63.57 × 10−7
     Ratio1.151.441.010.90NANA
    Liver
     OLINDA/EXM5.48 × 10−72.16 × 10−78.19 × 10−71.74 × 10−5NANA
     OEDIPE5.94 × 10−73.80 × 10−79.06 × 10−71.73 × 10−55.21 × 10−65.95 × 10−7
     Ratio0.920.560.901.01NANA
    Tumor in lung
     OLINDA/EXMNANANANA4.51 × 10−3NA
     OEDIPE2.29 × 10−72.15 × 10−62.18 × 10−65.06 × 10−64.41 × 10−32.23 × 10−7
    Tumor in liver
     OLINDA/EXMNANANANANA4.53 × 10−3
     OEDIPE2.96 × 10−62.72 × 10−63.57 × 10−75.95 × 10−72.20 × 10−74.41 × 10−3

    • OLINDA/EXM self values have been corrected for mass.

    • NA = not applicable.

  • TABLE 4

    Percentage Difference in Organ Doses Calculated with OLINDA/EXM from Doses Calculated with OEDIPE

    Patient no.
    OrganP1P2P3P4P5P6P7P8P9
    Lungs
     No correction−55.2−81.7−62.6−26.0−11.420.3−27.9−11.9−54.9
     Mass corrected−3.3−3.7−4.0−2.7−3.7−4.0−5.2−5.2−4.3
    Spleen
     No correction−140.9−128.654.417.4−131.7−41.8−88.0−18.3−0.2
     Mass corrected−1.2−2.0−0.2−5.3−1.8−0.3−5.0−2.4−1.7
    Kidneys
     No correction−92.2−116.4−64.4−36.2−73.1−90.1−116.7−130.7−75.8
     Mass corrected−2.0−2.52.6−2.8−4.11.80.5−0.70.7
    Liver
     No correction−21.0−55.43.528.69.713.3−35.2−19.3−37.4
     Mass corrected1.0−2.1−1.20.20.51.2−0.80.9−1.8
    Tumor in lung
     No correctionNANANANANANANANANA
     Mass corrected3.44.12.12.03.32.22.51.41.9
    Tumor in liver
     No correctionNANANANANANANANANA
     Mass corrected4.04.12.83.42.73.14.43.54.5

    • Table refers to biodistribution A (Table 2).

    • NA = not applicable.

  • TABLE 5

    Cross-Irradiation Contribution from Lungs and Hepatic Tumor to Total Liver Dose for 6 Biodistributions Studied for Patient P1

    Biodistribution% Contribution to total liver dose from lungs% Contribution to total liver dose from hepatic tumorTotal liver dose as calculated by OEDIPE (Gy)Total liver dose as calculated by OLINDA/EXM* (Gy)
    A4.00.61.781.76
    B7.61.21.861.79
    C14.02.12.031.92
    D24.13.72.352.18
    E37.75.73.002.70
    F52.68.04.313.73

    • ↵* Self-irradiation was corrected by OLINDA/EXM mass-correction algorithm, and cross-irradiation for reference man was used.

    • Distribution A was derived from Rizzieri et al. (24).

  • TABLE 6

    Percentage Difference of Liver Doses Calculated Using OLINDA/EXM* and OEDIPE for Biodistributions A–F

    Patient no.
    BiodistributionP1P2P3P4P5P6P7P8P9
    A−1.02.11.2−1.6−0.5−1.80.8−0.91.8
    B−3.92.30.6−4.0−2.3−3.00.4−1.91.7
    C−5.32.60.5−7.4−5.5−5.3−0.2−3.82.3
    D−7.43.20.3−12.6−10.6−9.2−1.3−6.63.2
    E−10.34.00.1−19.4−17.3−14.8−2.9−10.64.5
    F−13.44.8−0.1−26.5−24.7−21.8−4.9−15.46.0

    • ↵* Self-irradiation was corrected by OLINDA/EXM mass-correction algorithm, and cross-irradiation for reference man was used.

    • Distribution A was derived from Rizzieri et al. (24).

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