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Radiation Dosimetry of β-Amyloid Tracers 11C-PiB and 18F-BAY94-9172

Graeme J. O'Keefe, Timothy H. Saunder, Steven Ng, Uwe Ackerman, Henri J. Tochon-Danguy, J. Gordon Chan, Sylvia Gong, Thomas Dyrks, Stefanie Lindemann, Gerhard Holl, Ludger Dinkelborg, Victor Villemagne and Christopher C. Rowe
Journal of Nuclear Medicine February 2009, 50 (2) 309-315; DOI: https://doi.org/10.2967/jnumed.108.055756

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    Coronal projections (100 mm thick) of 3 sequential WB images (0, 30, and 60 min after injection of 11C-PiB) of subject 1. Images are displayed on SUV scale (range, 0–10), giving indication of differences in %IRDs.

  • FIGURE 2. 
    FIGURE 2. 

    Coronal projections (100 mm thick) of 3 sequential WB images (0, 60, and 180 min after injection of 18F-BAY94-9172) of subject 1. Images are displayed on SUV scale, giving indication of differences in %IRDs.

  • FIGURE 3. 
    FIGURE 3. 

    Coronal projections (100 mm thick) of WB images of 3 subjects 3 h after injection with 18F-BAY94-9172, illustrating variable levels of radioactivity in contents of large intestine.

  • FIGURE 4. 
    FIGURE 4. 

    11C-PiB time–activity curves for liver, brain, kidneys, and bladder contents, expressed as %IRD normalized to reference man (19). Variability represented by error bars resulted from differences in individual subjects, placement of regions of interest, and emission image statistics.

  • FIGURE 5. 
    FIGURE 5. 

    18F-BAY94-9172 time–activity curves for liver, brain, kidneys, and bladder contents, expressed as %IRD normalized to reference man (19). Variability represented by error bars resulted from differences in individual subjects, placement of regions of interest, and emission image statistics. High variability in bladder contents illustrated different patterns of individual bladder voiding.

Tables

  • TABLE 1

    Subject Details and Injected Radioactivities of 11C-PiB and 18F-BAY94-9172

    Tracer or parameterSubjectSexAge (y)Mass (kg)Injected dose (MBq)
    11C-PiB1F6368.5370.1
    2F5666.0377.7
    3F7061.0363.9
    4M6593.5344.3
    5M6479.0300.2
    6M6188.0352.1
    Mean ± SD63.2 ± 4.276.0 ± 11.8351.4 ± 25.4
    18F-BAY94-91721M63.5101299.3
    2M73.5103307.2
    3F63.166.9349.5
    Mean ± SD66.7 ± 4.890.3 ± 16.6318.7 ± 22.0
  • TABLE 2

    11C-PiB and 18F-BAY94-9172 WB Scanning Protocols

    TracerTime (min)Scan
    11C-PiB−10ldCT
    0WB1
    15WB2
    30WB3
    45WB4
    60WB5
    18F-BAY94-9172−20ldCT
    −5137Cs AC
    0WB1
    20WB2
    60WB3
    110137Cs AC
    120WB4
    170137Cs AC
    180WB5

    • Five WB scans (WB1–WB5) were done for each tracer. 137Cs transmission scan was repeated when subject was repositioned on scanner after being removed from scanner to allow for bladder voiding. AC = attenuation correction.

  • TABLE 3

    11C-PiB and 18F-BAY94-9172 Radiation Doses Determined With 73.7-kg Hermaphroditic Adult Phantom

    Mean ± SD dose of:
    Organ or parameter11C-PiB (n = 6)18F-BAY94-9172 (n = 3)
    Adrenal glands4.00 ± 0.3215.30 ± 1.56
    Brain3.92 ± 1.4410.28 ± 1.55
    Breasts2.21 ± 0.239.05 ± 0.56
    Gallbladder wall44.80 ± 29.30132.40 ± 43.40
    Lower large intestine wall3.10 ± 0.3515.73 ± 0.61
    Small intestine4.65 ± 0.7414.03 ± 0.42
    Stomach wall3.11 ± 0.2813.20 ± 1.04
    Upper large intestine wall3.87 ± 0.4317.83 ± 2.18
    Heart wall3.24 ± 0.3412.90 ± 0.96
    Kidneys12.92 ± 3.3720.03 ± 5.59
    Liver19.88 ± 3.5839.07 ± 8.31
    Lungs6.59 ± 3.318.26 ± 0.56
    Muscle2.57 ± 0.2410.90 ± 0.66
    Ovaries3.21 ± 0.3313.70 ± 0.80
    Pancreas4.02 ± 0.3315.93 ± 1.63
    Red marrow2.43 ± 0.2018.93 ± 4.28
    Osteogenic cells3.60 ± 0.4822.03 ± 4.16
    Skin1.98 ± 0.208.38 ± 0.43
    Spleen4.03 ± 0.5715.13 ± 7.02
    Testes2.12 ± 0.1010.06 ± 5.82
    Thymus2.54 ± 0.3111.07 ± 0.80
    Thyroid2.24 ± 0.2110.47 ± 0.35
    Urinary bladder wall26.30 ± 8.5024.77 ± 7.36
    Uterus3.73 ± 0.4213.83 ± 0.90
    Total body3.23 ± 0.3012.23 ± 0.95
    ED equivalent (μSv/MBq)8.93 ± 1.8023.17 ± 4.29
    ED (μSv/MBq)5.29 ± 0.6614.67 ± 1.39

    • Data are reported in μGy/MBq unless otherwise indicated.

  • TABLE 4

    Comparison of 11C-PiB Dosimetry from Scheinin et al. (26) and Present Study

    μGy/MBq from:
    OrganScheinin et al.Present study
    Gallbladder wall41.544.80 ± 29.30
    Urinary bladder wall16.626.30 ± 8.50
    Liver19.019.88 ± 3.58
    Kidney12.612.92 ± 3.37
    Upper large intestine wall9.03.87 ± 0.43
  • TABLE 5

    Comparison of ED (Adult Phantom Model) Estimates for 11C-PiB, 18F-BAY94-9172, and Other 18F-Labeled Pharmaceuticals

    Tracer (study)ED (μSv/MBq)
    11C-PiB5.29 ± 0.66
    11C-PiB (26)4.74
    18F-BAY94-917214.67 ± 1.39
    18F-FDG (22,23)19.0
    18F-A85380 (27)19.4
    99mTc-phosphonate* (23)5.7

    • ↵* Common SPECT agent.

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