Article Figures & Data
Figures
- FIGURE 1.
Sequential anterior whole-body γ-camera scans after injection of 111In-ibritumomab tiuxetan. Distribution is normal, and no evidence of residual tumor is seen.
- FIGURE 2.
Bone marrow and whole-body radiation doses in patients with PR or CR to initial therapy.
- FIGURE 3.
Correlation of PFS with whole-body (WB) radiation dose. Quartile 1 (Q1) = 0.55 mGy/MBq < WB radiation dose ≤ 0.62 mGy/MBq; quartile 2 (Q2) = 0.62 mGy/MBq < WB radiation dose ≤ 0.73 mGy/MBq; quartile 3 (Q3) = 0.73 mGy/MBq < WB radiation dose ≤ 0.83 mGy/MBq; quartile 4 (Q4) = 0.83 mGy/MBq < WB radiation dose ≤ 1.12 mGy/MBq.
Tables
- TABLE 1
Disposition and Demographics of Patients Who Received 111In-Ibritumomab Tiuxetan and Underwent Central Dosimetry Analysis
Characteristic Value Underwent central dosimetry (n) 57 Male (n) 26 (45.6%) Median age (y) 56 Age range (y) 30–78 Median body weight (kg) 71 Body weight range (kg) 46–107 Ann Arbor classification (n) Stage I* 1 (1.8%) Stage III 21 (36.8%) Stage IV 35 (61.4%) B symptoms (n) No 33 (57.9%) Yes 23 (40.3%) Response after first-line therapy (n) CR/unconfirmed CR 35 (61.4%) PR 22 (38.6%) First-line induction regimen (n) CHOP 10 (17.5%) CVP/COP 10 (17.5%) CHOP-like 6 (10.5%) Fludarabine 1 (1.8%) Chlorambucil 7 (12.3%) Rituximab combination 23 (40.4%) Bcl-2 RQ-PCR positive at time of randomization (n)† 12 (21.8%) FLIPI score (n)‡ High 1 (2.2%) Intermediate 12 (26.7%) Low 32 (71.1%) ↵* Protocol deviation.
↵† Based on 55 patients; data not available for 2 patients.
↵‡ Based on 45 patients; data not available for 12 patients.
CHOP = cyclophosphamide, doxorubicin, vincristine, and prednisone; CVP/COP = cyclophosphamide, vincristine, and prednisone; RQ-PCR = real-time quantitative polymerase chain reaction; FLIPI = Follicular Lymphoma International Prognostic Index.
Organ Median radiation absorbed dose (cGy) Radiation absorbed dose range (cGy) Lungs 113 57–268 Liver 352 108–860 Spleen 748 288–1,702 Kidneys 322 155–858 Red marrow 100 28–327 Whole body 72 46–106 Organ Median radiation absorbed dose (mGy/MBq) Radiation absorbed dose range (mGy/MBq) Bone marrow 0.976 0.312–3.453 Kidneys 3.078 1.368–9.753 Liver 3.580 0.915–7.264 Lungs 1.220 0.566–2.318 Spleen 6.834 3.157–16.670 Whole body 0.734 0.549–1.119 - TABLE 5
No Correlation Between Whole-Body or Bone Marrow Mean Radiation Absorbed Dose and Hematologic Toxicity
Mean radiation absorbed dose (cGy) Patient subgroups by toxicity grading Red marrow Whole body Mean SD Mean SD Thrombocytopenia Grade 3 or 4 178 129 84 20 Grade 0–2 100 38 73 12 Neutropenia Grade 3 or 4 97 47 80 16 Grade 0–2 103 37 73 11 Anemia Grade 0–2 104 48 74 12
