Article Figures & Data
Figures
- FIGURE 1.
A 79-y-old man, with lung cancer and bone metastases, treated with zoledronic acid. (A) Planar images showed gross area of tracer uptake in left maxilla, due to osteonecrosis, and mild focus in right mandible (arrow). (B) Hybrid SPECT/CT more precisely defined extension of osteonecrosis in left maxilla and better demonstrated focus in right mandible (triangulation). Focus was then confirmed as initial osteonecrosis by follow-up.
- FIGURE 2.
A 73-y-old woman, affected by multiple myeloma, previously treated with bisphosphonates. (A) Orthopantomography showed area of bone cortical irregularity (circled) in right mandible. (B) Three-phase bone scanning revealed increased blood pool (circled). (C) Hybrid SPECT/CT allowed definition of area of osteonecrosis (arrow) with neighboring hyperactive viable bone.
- FIGURE 3.
A 63-y-old woman with breast cancer and bone metastases treated with zoledronic acid for 2 y. (A) Orthopantomography showed area of cortical disruption (circled) in right mandible. (B) Three-phase bone scanning revealed increased blood pool (circled). (C) Hybrid SPECT/CT well demonstrated a necrotic core (arrow) and neighboring viable bone.
Tables
Reason for taking zoledronic acid 3-phase flow imaging Site of focal SPECT/CT hyperactivity Patient no. Age (y) Sex Site of necrosis Perfusion Blood pool Final diagnosis 1 54 F Bone metastases secondary to breast cancer Mandible and maxilla Increased in mandible Increased in mandible Mandible and mild in maxilla Necrosis in mandible and maxilla 2 74 F Bone metastases secondary to breast cancer Mandible Increased in mandible Increased in mandible Mandible Necrosis in mandible 3 80 M Bone metastases secondary to lung cancer Maxilla Increased in maxilla Increased in maxilla Maxilla and mild in mandible Necrosis in maxilla and afterward also in mandible 4 60 M Multiple myeloma Mandible and maxilla Increased in maxilla and mandible Increased in maxilla and mandible Maxilla and mandible Necrosis in mandible and maxilla 5 74 F Multiple myeloma Mandible Increased in mandible Increased in mandible Mandible Necrosis in mandible 6 78 F Multiple myeloma Mandible Negative for increase Negative for increase Mandible Necrosis in mandible 7 72 F Bone metastases secondary to breast cancer Mandible No flow imaging executed No flow imaging executed Mandible Necrosis in mandible 8 74 M Multiple myeloma Mandible Increased in mandible Increased in mandible Mandible Necrosis in mandible 9 86 F Bone metastases secondary to breast cancer Mandible No flow imaging executed No flow imaging executed Mandible Necrosis in mandible 10 65 F Bone metastases secondary to breast cancer Mandible No flow imaging executed No flow imaging executed Mandible Necrosis in mandible 11 74 F Bone metastases secondary to breast cancer Mandible Negative for increase Increased in mandible Mandible Necrosis in mandible 12 74 F Bone metastases secondary to breast cancer Mandible Increased in mandible Increased in mandible Mandible Necrosis in mandible 13 71 F Bone metastases secondary to breast cancer Maxilla Increased in mandible Increased in mandible Mandible and maxilla Necrosis in maxilla and afterward also in mandible 14 61 F Bone metastases secondary to breast cancer Maxilla Negative for increase Negative for increase Maxilla Necrosis in maxilla 15 64 F Bone metastases secondary to lung cancer Maxilla Increased in maxilla Increased in maxilla Maxilla Necrosis in maxilla
