Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleCLINICAL INVESTIGATIONS

68Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with 18F-FDG

Antonia Dimitrakopoulou-Strauss, Peter Hohenberger, Uwe Haberkorn, Helmut R. Mäcke, Michael Eisenhut and Ludwig G. Strauss
Journal of Nuclear Medicine August 2007, 48 (8) 1245-1250; DOI: https://doi.org/10.2967/jnumed.106.038091
Antonia Dimitrakopoulou-Strauss
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Hohenberger
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Uwe Haberkorn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helmut R. Mäcke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Eisenhut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ludwig G. Strauss
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1. 
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1. 

    Patient with recurrent GIST in stomach. (A) Transaxial 18F-FDG image (SUV image) at level of upper abdomen shows no significantly enhanced 18F-FDG uptake in stomach. (B) Corresponding transaxial bombesin image (SUV image) at level of upper abdomen shows enhanced bombesin uptake in stomach (SUV, 9.3).

  • FIGURE 2. 
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2. 

    (A) CT image of patient with metastatic GIST demonstrates soft-tissue mass medial to spleen. (B) Transaxial 18F-FDG image (SUV image) at level of CT image shows enhanced 18F-FDG uptake (SUV, 3.2) at location of CT finding. (C) Corresponding transaxial bombesin image (SUV image) at level of CT image shows slightly enhanced bombesin uptake (SUV, 2.0) at location of CT finding.

  • FIGURE 3. 
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3. 

    (Top left) Transaxial 18F-FDG image (SUV image) at level of liver demonstrates 2 hypermetabolic areas, one in ventral part of right liver lobe (SUV, 5.8) and another in stomach (SUV, 17.1), in patient with metastatic GIST. (Top right) CT image at same level demonstrates the 2 hypodense lesions in stomach and liver. (Bottom left) Transaxial bombesin image (SUV image) at level of CT image demonstrates clearly enhanced bombesin uptake only in liver lesion (SUV, 2.6). Bombesin uptake in stomach shows slight diffuse enhancement. (Bottom right) Fused image of 18F-FDG and bombesin transaxial slice shows an agreement for both tracers in the liver lesion, whereas the enhanced 18F-FDG uptake in the stomach is assigned to a low-bombesin-uptake area. Histology revealed recurrent stomach tumor and liver metastasis.

  • FIGURE 4. 
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 4. 

    (A) Box-and-whisker plot of median SUV for both tracers 56–60 min after injection in malignant lesions. (B) Box-and-whisker plot of median values for both tracers for VB, k1, and k3 in malignant lesions.

Tables

  • Figures
    • View popup
    TABLE 1

    Data Summary

    RadiopharmaceuticalParameterMedianMeanMinimumMaximum
    18F-FDGk10.5440.5800.1990.961
    k20.8030.7800.5000.999
    k30.0920.1070.0030.314
    k40.0030.0060.0000.023
    VB0.1230.1270.0290.253
    Fractal dimension1.3761.3511.1581.440
    SUV7.8468.4222.39517.000
    68Ga-BZH3k10.5000.5000.3770.612
    k20.5900.5800.2180.902
    k30.0220.0470.0000.189
    k40.0010.0250.0000.134
    VB0.1880.2310.0500.588
    Fractal dimension1.2141.1600.8701.400
    SUV3.2703.2700.5369.253
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 48 (8)
Journal of Nuclear Medicine
Vol. 48, Issue 8
August 2007
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
68Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with 18F-FDG
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
68Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with 18F-FDG
Antonia Dimitrakopoulou-Strauss, Peter Hohenberger, Uwe Haberkorn, Helmut R. Mäcke, Michael Eisenhut, Ludwig G. Strauss
Journal of Nuclear Medicine Aug 2007, 48 (8) 1245-1250; DOI: 10.2967/jnumed.106.038091

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
68Ga-Labeled Bombesin Studies in Patients with Gastrointestinal Stromal Tumors: Comparison with 18F-FDG
Antonia Dimitrakopoulou-Strauss, Peter Hohenberger, Uwe Haberkorn, Helmut R. Mäcke, Michael Eisenhut, Ludwig G. Strauss
Journal of Nuclear Medicine Aug 2007, 48 (8) 1245-1250; DOI: 10.2967/jnumed.106.038091
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • Gastrin-Releasing Peptide Receptor Imaging and Therapy in the Era of Personalized Medicine
  • Head-to-Head Comparison of [68Ga]Ga-NOTA-RM26 and [18F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study
  • MITIGATE-NeoBOMB1, a Phase I/IIa Study to Evaluate Safety, Pharmacokinetics, and Preliminary Imaging of 68Ga-NeoBOMB1, a Gastrin-Releasing Peptide Receptor Antagonist, in GIST Patients
  • Bombesin-Targeted PET of Prostate Cancer
  • "To Serve and Protect": Enzyme Inhibitors as Radiopeptide Escorts Promote Tumor Targeting
  • Radiopeptide Imaging and Therapy in Europe
  • Evaluation of a 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid-Conjugated Bombesin-Based Radioantagonist for the Labeling with Single-Photon Emission Computed Tomography, Positron Emission Tomography, and Therapeutic Radionuclides
  • Peptide-Based Probes for Cancer Imaging
  • Therapeutic Consequences from Molecular Biology for Gastrointestinal Stromal Tumor Patients Affected by Neurofibromatosis Type 1
  • International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States
  • Google Scholar

More in this TOC Section

  • Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System
  • Cardiac Presynaptic Sympathetic Nervous Function Evaluated by Cardiac PET in Patients with Chronotropic Incompetence Without Heart Failure
  • Validation and Evaluation of a Vendor-Provided Head Motion Correction Algorithm on the uMI Panorama PET/CT System
Show more Clinical Investigations

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire