Article Figures & Data
Figures
- FIGURE 1.
Representative images of T2-weighted MRI (A and D), diffusion-weighted MRI (B and E), and perfusion SPECT (C and F). (A–C) Patient with severe aphasia (AQ = 57.4 points) shows severe extensive left cerebral cortical hypoperfusion (AI of cerebral cortex = 14.93). (D–F) Another patient with mild aphasia (AQ = 90.9 points) had only mild hypoperfusion in left parietal cortex (AI of cerebral cortex = 2.53).
- FIGURE 2.
Comparisons of regional AIs between healthy control subjects and patients. F = frontal cortex; T = temporal cortex; P = parietal cortex; O = occipital cortex; Cx = whole cerebral cortex; Cb = cerebellar cortex; BG = basal ganglia; Th = thalamus; CI = confidence interval.
- FIGURE 3.
Voxel-based SPM analysis shows significant voxels on SPECT data to correlate with the AQ. Perfusion of left temporal cortex and right cerebellum was positively correlated with the AQ.
Tables
Patient no. Age (y) Aphasia type AQ (points) Infarct size (mm) Regional asymmetric index on brain perfusion SPECT Sex MRA F T P O Cx Cb BG Th 1 80 F Global 6.8 38 M1 occlusion 3.42 2.93 10.11 0.58 5.72 −4.23 27.21 9.63 2 75 M Global 13.0 36 M1 occlusion 8.33 5.89 11.53 2.66 8.61 −8.41 22.04 9.59 3 67 M TS 53.4 37 Normal 2.78 3.46 7.34 5.26 5.40 −4.26 43.38 3.14 4 64 F Mixed T 54.0 28 M1 occlusion 3.34 4.81 12.47 3.49 6.92 −4.03 28.79 4.22 5 67 F TS 57.4 39 M1 occlusion 13.43 14.25 18.01 8.68 14.93 2.62 35.57 9.79 6 77 F Mixed T 66.0 33 M1 occlusion 4.86 5.78 9.51 −1.25 6.29 −2.29 22.14 4.75 7 68 M Mixed T 67.5 44 Normal 4.21 3.06 7.71 −1.26 4.67 −3.80 28.46 4.05 8 49 M TM 79.2 30 Normal −0.27 0.95 6.55 −0.49 2.15 0.52 34.00 3.92 9 68 F Anomic 80.3 31 Normal 1.43 −1.85 8.60 2.48 3.88 −0.26 16.09 0.25 10 67 M TM 81.6 28 Normal 2.10 −4.10 5.20 −2.68 1.46 0.83 18.06 1.17 11 75 F Anomic 84.4 18 M1 stenosis −3.84 −5.79 7.55 4.33 0.73 3.71 11.34 −1.20 12 63 F Anomic 86.8 22 Normal 4.18 −1.41 8.86 1.69 4.84 0.80 28.08 −1.39 13 46 M Anomic 87.6 40 Normal 0.21 1.23 7.08 2.97 3.63 −2.03 29.55 3.42 14 56 M Anomic 88.8 11 M1 stenosis −2.88 −4.56 7.44 −1.02 0.65 1.62 11.25 −3.71 15 56 F Anomic 90.9 22 Normal −1.07 −1.92 5.73 5.33 2.53 1.06 14.14 −0.54 16 58 M Normal 95.1 27 Normal 1.64 −4.55 4.45 2.08 2.13 4.61 30.62 3.43 MRA = MR angiography; F = frontal cortex; T = temporal cortex; P = parietal cortex; O = occipital cortex; Cx = whole cerebral cortex; Cb = cerebellar cortex; BG = basal ganglia; Th = thalamus; M1 = horizontal segment of middle cerebral artery; TS = transcortical sensory; mixed T = mixed transcortical; TM = transcortical motor.
Correlation with AQ Correlation with infarct size Correlation with age AI Mean ± SD Range ρ P value ρ P value ρ P value Frontal cortex 2.62 ± 4.19 −3.84 ∼ 13.43 −0.653 <0.01 0.594 <0.05 0.532 <0.05 Temporal cortex 1.14 ± 5.21 −5.79 ∼ 14.25 −0.782 <0.001 0.729 0.001 0.379 NS Parietal cortex 8.63 ± 3.30 4.45 ∼ 18.01 −0.694 <0.005 0.328 NS 0.597 <0.05 Occipital cortex 2.05 ± 3.01 −2.68 ∼ 8.68 −0.053 NS 0.010 NS 0.321 NS Whole cerebral cortex 4.66 ± 3.57 0.65 ∼ 14.93 −0.768 0.001 0.599 <0.05 0.491 NS Cerebellar cortex −0.85 ± 3.49 −8.41 ∼ 4.61 0.765 0.001 −0.588 <0.05 −0.388 NS Basal ganglia 25.05 ± 9.17 11.25 ∼ 43.38 −0.312 NS 0.560 <0.05 −0.206 NS Thalamus 3.16 ± 4.04 −3.71 ∼ 9.79 −0.721 <0.005 0.713 <0.005 0.453 NS Infarct size (mm) 30 ± 9 11 ∼ 44 −0.594 <0.05 NA NA 0.311 NS Age (y) 64.8 ± 9.6 46.4 ∼ 79.6 −0.665 0.005 0.311 NS NA NA NS = not significant; NA = not applicable.
