The Radioactive Drug Research Committee: Background and Retrospective Study of Reported Research Data (1975–2004)

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FIGURE 1.
Number and status of RDRCs by 5-Year Reporting Periods

TABLE 1

RDRC Research: Number of Studies and Number of Human Subjects by Year

Year	RDRC studies (n)	RDRC subjects (n)	Studies with pediatric subjects (n)	Pediatric subjects (n)	Studies with pediatric subjects (%)	All subjects who were pediatric (%)
1976	18	531	3	39	16.7% (3/18)	7.3% (39/531)
1981	224	2,088	12	58	5.4% (12/224)	2.8% (58/2,088)
1986	207	2,310	8	80	3.9% (8/207)	3.5% (80/2,310)
1991	245	2,833	9	80	3.7% (9/245)	2.8% (80/2,833)
1996	243	1,958	6	32	2.5% (6/243)	1.6% (32/1,958)
2001	153	1,108	0	0	0	0
2002	280	2,872	0	0	0	0
2003	284	2,797	0	0	0	0

TABLE 2

Number of Active Studies per Active RDRC in 2003

Committees conducting studies	Active studies (n)	Human subjects (n)	All 2003 human subjects (%)
A	31	266	9.5
B	34	251	9.0
C	14	242	8.7
D	14	214	7.7
E	16	211	7.5
F	25	193	6.9
G	15	162	5.8
H	12	154	5.5
I	16	121	4.3
J	5	116	4.1
K	7	87	3.1
L	14	85	3.0
M	18	80	2.9
N	8	68	2.4
O	2	66	2.4
Remaining 39 committees	53	481	17 (<2% for each remaining committee)
Total: 54 active	Total: 284	Total: 2,797	100

TABLE 4

Percentages of Specific Radionuclides Used in 2003 RDRC Studies by Imaging Type^*

↵* Radioactive drug research studies conducted in 2003: 84 committees, 284 studies, 2,797 human subjects.
Values in alternate columns are expressed as percentages.

TABLE 5

Use of Multiple Nuclides in RDRC Studies by Year and Number of Nuclides

Year	Studies with 1 nuclide (%)	Studies with 2 nuclides (%)	Studies with 3 nuclides (%)	Studies with 4 nuclides (%)
1976	92.3	7.7	0	0
1981	94.9	3.4	0.6	1.1
1986	93.3	4.5	2.2	0
1991	82.1	16.4	1.5	0
1996	88.2	11.0	0.9	0
2001	72.5	23.9	3.5	0