OtherBASIC SCIENCE INVESTIGATIONS

Organ and Fetal Absorbed Dose Estimates from 99mTc-Sulfur Colloid Lymphoscintigraphy and Sentinel Node Localization in Breast Cancer Patients

Neeta Pandit-Taskar, Lawrence T. Dauer, Leslie Montgomery, Jean St. Germain, Pat B. Zanzonico and Chaitanya R. Divgi
Journal of Nuclear Medicine July 2006, 47 (7) 1202-1208;

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    Anterior (A) and right lateral (B) transmission images obtained 30 min after lymphoscintigraphic injection in left breast show injection site (solid arrow) and focal uptake (dashed arrow) in sentinel node in right axilla.

Tables

  • TABLE 1

    Doses (mGy/MBq) from Combined Sources (Injected Breast + Total Body) to Adult Nonpregnant Female Models

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals1.95E−031.76E−031.83E−03
    Brain1.50E−041.35E−041.40E−04
    Injected breast8.04E−012.97E−014.04E−01
    Gallbladder wall1.46E−031.32E−031.36E−03
    LLI wall1.80E−041.62E−041.68E−04
    Small intestine3.69E−043.33E−043.45E−04
    Stomach wall2.55E−032.31E−032.40E−03
    ULI wall5.38E−044.87E−045.05E−04
    Heart wall1.05E−029.49E−039.84E−03
    Kidneys8.30E−047.51E−047.79E−04
    Liver2.83E−032.56E−032.66E−03
    Lungs7.90E−037.16E−037.42E−03
    Muscle1.74E−031.57E−031.63E−03
    Ovaries1.79E−041.62E−041.68E−04
    Pancreas2.41E−032.18E−032.26E−03
    Red marrow1.90E−031.71E−031.78E−03
    Osteogenic cells3.11E−032.81E−032.91E−03
    Skin2.82E−032.56E−032.65E−03
    Spleen1.67E−031.51E−031.57E−03
    Thymus9.99E−039.05E−039.38E−03
    Thyroid1.27E−031.15E−031.20E−03
    Bladder wall1.46E−041.32E−041.37E−04
    Uterus1.88E−041.70E−041.77E−04
    Fetus0.00E+000.00E+000.00E+00
    Placenta0.00E+000.00E+000.00E+00
    Total body4.11E−033.67E−033.83E−03
    Effective dose (mSv/MBq)2.47E−029.90E−031.31E−02
  • TABLE 2

    Doses (mGy/MBq) from Combined Sources (Injected Breast + Total Body) to 3-Month-Pregnant Models

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals1.94E−031.76E−031.83E−03
    Brain1.50E−041.35E−041.41E−04
    Injected breast8.04E−012.97E−014.04E−01
    Gallbladder wall1.45E−031.32E−031.36E−03
    LLI wall1.73E−041.55E−041.62E−04
    Small intestine4.14E−043.75E−043.89E−04
    Stomach wall2.54E−032.30E−032.39E−03
    ULI wall5.27E−044.78E−044.96E−04
    Heart wall1.05E−029.49E−039.84E−03
    Kidneys8.28E−047.50E−047.77E−04
    Liver2.83E−032.56E−032.66E−03
    Lungs7.90E−037.16E−037.42E−03
    Muscle1.74E−031.57E−031.63E−03
    Ovaries1.71E−041.55E−041.60E−04
    Pancreas2.41E−032.18E−032.26E−03
    Red marrow1.90E−031.71E−031.78E−03
    Osteogenic cells3.11E−032.81E−032.91E−03
    Skin2.82E−032.56E−032.65E−03
    Spleen1.67E−031.51E−031.56E−03
    Thymus9.99E−039.05E−039.38E−03
    Thyroid1.27E−031.15E−031.20E−03
    Bladder wall1.21E−041.09E−041.13E−04
    Uterus1.76E−041.59E−041.65E−04
    Fetus2.06E−041.85E−041.92E−04
    Placenta0.00E+000.00E+000.00E+00
    Total body4.11E−033.67E−033.83E−03
    Effective dose (mSv/MBq)2.47E−029.90E−031.30E−02
  • TABLE 3

    Doses (mGy/MBq) from Combined Sources (Injected Breast + Total Body) to 6-Month-Pregnant Models

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals1.94E−031.76E−031.83E−03
    Brain1.46E−041.31E−041.36E−04
    Injected breast8.04E−012.97E−014.04E−01
    Gallbladder wall1.59E−031.44E−031.49E−03
    LLI wall4.12E−043.74E−043.88E−04
    Small intestine6.08E−045.49E−045.71E−04
    Stomach wall3.19E−032.88E−032.99E−03
    ULI wall1.63E−031.47E−031.53E−03
    Heart wall1.16E−021.05E−021.09E−02
    Kidneys8.27E−047.49E−047.76E−04
    Liver3.35E−033.03E−033.15E−03
    Lungs8.17E−037.40E−037.68E−03
    Muscle1.75E−031.58E−031.64E−03
    Ovaries1.95E−041.77E−041.83E−04
    Pancreas2.41E−032.18E−032.26E−03
    Red marrow1.90E−031.71E−031.78E−03
    Osteogenic cells3.10E−032.80E−032.91E−03
    Skin2.92E−032.65E−032.75E−03
    Spleen1.67E−031.51E−031.56E−03
    Thymus8.83E−038.00E−038.29E−03
    Thyroid1.27E−031.15E−031.19E−03
    Bladder wall1.34E−041.21E−041.26E−04
    Uterus6.86E−046.20E−046.44E−04
    Fetus6.18E−045.59E−045.81E−04
    Placenta1.30E−031.18E−031.22E−03
    Total body3.99E−033.56E−033.71E−03
    Effective dose (mSv/MBq)2.49E−021.01E−021.32E−02
  • TABLE 4

    Doses (mGy/MBq) from Combined Sources (Injected Breast + Total Body) to 9-Month-Pregnant Models

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals1.94E−031.76E−031.83E−03
    Brain1.46E−041.32E−041.37E−04
    Injected breast8.04E−012.97E−014.04E−01
    Gallbladder wall1.58E−031.43E−031.49E−03
    LLI wall3.18E−042.88E−042.99E−04
    Small intestine1.89E−031.71E−031.78E−03
    Stomach wall3.19E−032.88E−032.99E−03
    ULI wall1.82E−031.65E−031.71E−03
    Heart wall1.16E−021.05E−021.09E−02
    Kidneys8.26E−047.48E−047.75E−04
    Liver3.35E−033.03E−033.15E−03
    Lungs8.17E−037.40E−037.68E−03
    Muscle1.80E−031.62E−031.68E−03
    Ovaries1.96E−041.77E−041.83E−04
    Pancreas2.40E−032.18E−032.26E−03
    Red marrow1.90E−031.71E−031.78E−03
    Osteogenic cells3.10E−032.80E−032.91E−03
    Skin2.98E−032.70E−032.80E−03
    Spleen1.67E−031.51E−031.56E−03
    Thymus8.83E−038.00E−038.29E−03
    Thyroid1.27E−031.15E−031.19E−03
    Bladder wall1.25E−041.13E−041.17E−04
    Uterus8.63E−047.81E−048.10E−04
    Fetus7.39E−046.69E−046.94E−04
    Placenta1.58E−031.44E−031.49E−03
    Total body4.04E−033.61E−033.77E−03
    Effective dose (mSv/MBq)2.49E−021.00E−021.32E−02
  • TABLE 5

    Fraction of Combined Doses from Injected Breast

    OrganFraction
    Bladder wall0.65
    Brain0.70
    Ovaries0.70
    LLI wall0.84
    Kidneys0.93
    Fetus0.95
    Uterus0.95
    Osteogenic cells0.95
    Thyroid0.96
    Gallbladder wall0.96
    Spleen0.97
    Adrenals0.97
    Small intestine0.97
    Pancreas0.97
    Red marrow0.97
    Muscle0.97
    ULI wall0.98
    Placenta0.98
    Liver0.98
    Stomach wall0.98
    Total body0.99
    Skin0.99
    Lungs0.99
    Thymus0.99
    Heart wall0.99
    Injected breast1.00
  • TABLE 6

    Doses (mSv) to 9-Month-Pregnant Models from 3.7-MBq 1-Day Protocol

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals7.19E−036.50E−036.76E−03
    Brain5.39E−044.87E−045.06E−04
    Injected breast2.97E+001.10E+001.49E+00
    Gallbladder wall5.84E−035.30E−035.49E−03
    LLI wall1.18E−031.07E−031.11E−03
    Small intestine6.99E−036.34E−036.57E−03
    Stomach wall1.18E−021.07E−021.11E−02
    ULI wall6.73E−036.09E−036.32E−03
    Heart wall4.28E−023.87E−024.02E−02
    Kidneys3.05E−032.77E−032.87E−03
    Liver1.24E−021.12E−021.16E−02
    Lungs3.02E−022.74E−022.84E−02
    Muscle6.64E−036.00E−036.23E−03
    Ovaries7.25E−046.55E−046.77E−04
    Pancreas8.90E−038.06E−038.36E−03
    Red marrow7.03E−036.34E−036.57E−03
    Osteogenic cells1.15E−021.04E−021.08E−02
    Skin1.10E−029.99E−031.04E−02
    Spleen6.17E−035.60E−035.79E−03
    Thymus3.27E−022.96E−023.07E−02
    Thyroid4.69E−034.27E−034.42E−03
    Bladder wall4.62E−044.17E−044.33E−04
    Uterus3.19E−032.89E−033.00E−03
    Fetus2.73E−032.48E−032.57E−03
    Placenta5.85E−035.32E−035.51E−03
    Total body1.49E−021.34E−021.39E−02
    Effective dose9.19E−023.72E−024.90E−02
  • TABLE 7

    Doses (mSv) to 9-Month-Pregnant Models from 18.5-MBq 2-Day Protocol

    OrganReference modelMSKCC modelMSKCC childbearing model
    Adrenals3.59E−023.25E−023.38E−02
    Brain2.70E−032.44E−032.53E−03
    Injected breast1.49E+015.49E+007.47E+00
    Gallbladder wall2.92E−022.65E−022.75E−02
    LLI wall5.89E−035.33E−035.53E−03
    Small intestine3.50E−023.17E−023.28E−02
    Stomach wall5.89E−025.33E−025.53E−02
    ULI wall3.37E−023.04E−023.16E−02
    Heart wall2.14E−011.93E−012.01E−01
    Kidneys1.53E−021.38E−021.43E−02
    Liver6.20E−025.61E−025.82E−02
    Lungs1.51E−011.37E−011.42E−01
    Muscle3.32E−023.00E−023.11E−02
    Ovaries3.63E−033.27E−033.39E−03
    Pancreas4.45E−024.03E−024.18E−02
    Red marrow3.51E−023.17E−023.28E−02
    Osteogenic cells5.74E−025.18E−025.38E−02
    Skin5.52E−024.99E−025.18E−02
    Spleen3.09E−022.80E−022.89E−02
    Thymus1.63E−011.48E−011.53E−01
    Thyroid2.35E−022.13E−022.21E−02
    Bladder wall2.31E−032.08E−032.16E−03
    Uterus1.60E−021.44E−021.50E−02
    Fetus1.37E−021.24E−021.28E−02
    Placenta2.93E−022.66E−022.75E−02
    Total body7.47E−026.69E−026.97E−02
    Effective dose4.60E−011.86E−012.45E−01
  • TABLE 8

    Comparison of Estimated Doses (mSv) to 9-Month-Pregnant Models from 18.5-MBq (0.5 mCi) 2-Day Protocol with Literature Estimates

    OrganReference modelMSKCC modelMSKCC childbearing modelZanzonico (26)
    Injected breast1.49E+015.49E+007.47E+001.10E+01
    Heart wall2.14E−011.93E−012.01E−013.20E−01
    Liver6.20E−025.61E−025.82E−021.60E−02 to 2.40E−01
    Lungs1.51E−011.37E−011.42E−011.20E−01
    Ovaries3.63E−033.27E−033.39E−03∼0 to 8.90E−02
    Thymus1.63E−011.48E−011.53E−011.50E−01
    Total body7.47E−026.69E−026.97E−028.10E−03 to 7.3E−02
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