Article Figures & Data
Figures
- FIGURE 1.
Right ventricular activity concentration curve after bolus injection. Dotted line represents monoexponential fit to downslope of activity concentration curve with forward extrapolation to correct for recirculation. Cardiac output is calculated as injected dose divided by area under concentration curve corrected for recirculation.
- FIGURE 2.
Acetate clearance rate k2, a measure of MVO2 rate (A); coefficient of variation of k2 between myocardial walls (B); SVI (C); cardiac efficiency in patients with severe heart failure and LBBB (n = 16) at baseline, after 4 mo, and after 13 mo of CRT (D). Values are mean ± SD. *P < 0.05 vs. 4 mo and 13 mo of CRT. Dotted horizontal line indicates mean value of corresponding parameter of comparison group with mild heart failure patients without LBBB (n = 13) and dashed lines indicate mean ± SD.
Tables
Patient no. Sex Age (y) QRS width (ms) NYHA class LVEF (%) LVEDD (mm) 1 F 64 180 3 16 84 2 M 62 200 3 25 88 3 M 68 180 3 14 93 4 F 69 176 3 25 75 5 M 71 200 3 20 83 6 F 63 235 3 22 74 7 F 74 192 3 18 86 8 M 62 220 3 19 112 9 M 58 186 3 30 62 10 F 70 184 3 23 69 11 M 74 180 3 18 79 12 F 57 220 3 26 62 13 F 65 160 3 20 85 14 F 48 186 3 25 79 15 M 53 184 3 10 89 16 F 32 180 3 25 94 Mean ± SD 62 ± 11 191 ± 19 21 ± 5 82 ± 13 LVEF = left ventricular ejection fraction; LVEDD = left ventricular end-diastolic diameter.
- TABLE 2
Characteristics of Comparison Group: Patients With Mild Heart Failure Without LBBB
Patient no. Sex Age (y) QRS width (ms) NYHA class LVEF (%) LVEDD (mm) 1 M 55 100 3 28 66 2 F 55 120 2 47 62 3 M 64 120 2 38 74 4 F 56 80 1 52 60 5 M 23 80 2 48 53 6 M 53 100 2 48 74 7 M 29 100 2 49 62 8 M 49 100 2 38 96 9 M 17 80 1 60 60 10 F 40 120 2 48 66 11 M 65 120 2 50 72 12 M 49 120 2 52 82 13 M 57 80 2 50 63 Mean ± SD 47 ± 15 102 ± 17 47 ± 8 68 ± 11 P vs. LBBB group NS 0.005 <0.0001 <0.0001 0.0008 0.005 LVEF = left ventricular ejection fraction; LVEDD = left ventricular end-diastolic diameter; NS = not significant.
Severe heart failure with LBBB Parameter Baseline 4 mo of CRT 13 mo of CRT Mild heart failure without LBBB Heart rate (bpm) 74 ± 13 72 ± 11 65 ± 9 69 ± 11 Systolic BP (mm Hg) 105 ± 27* 113 ± 21 113 ± 23 129 ± 25 Diastolic BP (mm Hg) 68 ± 10* 68 ± 14* 64 ± 12* 81 ± 13 k2 (min−1) 0.081 ± 0.015* 0.082 ± 0.016* 0.086 ± 0.020 0.099 ± 0.023 CV of regional k2 0.112 ± 0.048* 0.066 ± 0.038† 0.069 ± 0.039† 0.063 ± 0.014 SVI (mL/m2) 38 ± 16* 50 ± 15† 57 ± 12† 55 ± 17 CE (106 × mL/m2 × mm Hg) 3.47 ± 1.34* 4.91 ± 1.35† 4.85 ± 1.29† 4.77 ± 0.72
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