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Research ArticleCLINICAL INVESTIGATIONS

Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy

Oliver Lindner, Jens Sörensen, Jürgen Vogt, Eva Fricke, Detlev Baller, Dieter Horstkotte and Wolfgang Burchert
Journal of Nuclear Medicine March 2006, 47 (3) 378-383;
Oliver Lindner
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Jens Sörensen
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Jürgen Vogt
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Eva Fricke
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Detlev Baller
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Dieter Horstkotte
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Wolfgang Burchert
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  • FIGURE 1. 
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    FIGURE 1. 

    Right ventricular activity concentration curve after bolus injection. Dotted line represents monoexponential fit to downslope of activity concentration curve with forward extrapolation to correct for recirculation. Cardiac output is calculated as injected dose divided by area under concentration curve corrected for recirculation.

  • FIGURE 2. 
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    FIGURE 2. 

    Acetate clearance rate k2, a measure of MVO2 rate (A); coefficient of variation of k2 between myocardial walls (B); SVI (C); cardiac efficiency in patients with severe heart failure and LBBB (n = 16) at baseline, after 4 mo, and after 13 mo of CRT (D). Values are mean ± SD. *P < 0.05 vs. 4 mo and 13 mo of CRT. Dotted horizontal line indicates mean value of corresponding parameter of comparison group with mild heart failure patients without LBBB (n = 13) and dashed lines indicate mean ± SD.

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    TABLE 1

    Characteristics of Patients with Severe Heart Failure and LBBB

    Patient no.SexAge (y)QRS width (ms)NYHA classLVEF (%)LVEDD (mm)
    1F6418031684
    2M6220032588
    3M6818031493
    4F6917632575
    5M7120032083
    6F6323532274
    7F7419231886
    8M62220319112
    9M5818633062
    10F7018432369
    11M7418031879
    12F5722032662
    13F6516032085
    14F4818632579
    15M5318431089
    16F3218032594
    Mean ± SD62 ± 11191 ± 1921 ± 582 ± 13
    • LVEF = left ventricular ejection fraction; LVEDD = left ventricular end-diastolic diameter.

    • View popup
    TABLE 2

    Characteristics of Comparison Group: Patients With Mild Heart Failure Without LBBB

    Patient no.SexAge (y)QRS width (ms)NYHA classLVEF (%)LVEDD (mm)
    1M5510032866
    2F5512024762
    3M6412023874
    4F568015260
    5M238024853
    6M5310024874
    7M2910024962
    8M4910023896
    9M178016060
    10F4012024866
    11M6512025072
    12M4912025282
    13M578025063
    Mean ± SD47 ± 15102 ± 1747 ± 868 ± 11
    P vs. LBBB groupNS0.005<0.0001<0.00010.00080.005
    • LVEF = left ventricular ejection fraction; LVEDD = left ventricular end-diastolic diameter; NS = not significant.

    • View popup
    TABLE 3

    Hemodynamic, MVO2, and Efficiency Data

    Severe heart failure with LBBB
    ParameterBaseline4 mo of CRT13 mo of CRTMild heart failure without LBBB
    Heart rate (bpm)74 ± 1372 ± 1165 ± 969 ± 11
    Systolic BP (mm Hg)105 ± 27*113 ± 21113 ± 23129 ± 25
    Diastolic BP (mm Hg)68 ± 10*68 ± 14*64 ± 12*81 ± 13
    k2 (min−1)0.081 ± 0.015*0.082 ± 0.016*0.086 ± 0.0200.099 ± 0.023
    CV of regional k20.112 ± 0.048*0.066 ± 0.038†0.069 ± 0.039†0.063 ± 0.014
    SVI (mL/m2)38 ± 16*50 ± 15†57 ± 12†55 ± 17
    CE (106 × mL/m2 × mm Hg)3.47 ± 1.34*4.91 ± 1.35†4.85 ± 1.29†4.77 ± 0.72
    • ↵* P < 0.05 vs. comparison group with mild heart failure.

    • ↵† P < 0.05 vs. baseline.

    • BP = blood pressure; k2 = acetate clearance rate, a measure of MVO2 rate; CV = coefficient of variation; CE = cardiac efficiency.

    • Values are mean ± SD.

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Journal of Nuclear Medicine: 47 (3)
Journal of Nuclear Medicine
Vol. 47, Issue 3
March 2006
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Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy
Oliver Lindner, Jens Sörensen, Jürgen Vogt, Eva Fricke, Detlev Baller, Dieter Horstkotte, Wolfgang Burchert
Journal of Nuclear Medicine Mar 2006, 47 (3) 378-383;

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Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy
Oliver Lindner, Jens Sörensen, Jürgen Vogt, Eva Fricke, Detlev Baller, Dieter Horstkotte, Wolfgang Burchert
Journal of Nuclear Medicine Mar 2006, 47 (3) 378-383;
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