Article Figures & Data
Figures
- FIGURE 1.
Schematic diagram to illustrate circulation of PBSCs in major organs and migration of PBSCs to marrow with a half-life of τhome cleared from blood.
- FIGURE 2.
Effect of 90Y concentration on survival of GM-CFUs from stem cells in cell cultures.
- FIGURE 3.
Calculated PBSC survival as function of infusion time for patient receiving 2.0 GBq 90Y-2IT-BAD-m170, given patient-specific tissue effective half-lives and radiation doses (Table 3).
- FIGURE 4.
Isosurvival curves for planning time for PBSC infusion. Isosurvival curves of 70%, 80%, and 90% were determined as function of injection dose and infusion time.
Tables
Organ Mass (g) Fraction of total blood volume (%) Liver 1,800 10.0 Spleen 150 1.4 Lungs 1,200 12.5 Kidneys 310 2.0 Skeleton 10,500 7.0 Bone 5,500 Cortical bone 4,400 1.2 Trabecular bone 1,100 0.8 Red marrow 1,170 4.0 Remainder of body 59,040 67.1 Remainder of blood 67.1 Total blood 100 Data are from (26.
Tissue Teff (h) Dose (mGy/MBq) Liver NA 4.8 Spleen 58 2.8 Kidneys 50 1.9 Lungs 43 1.7 Marrow (imaging L2–L4) 60 1.6 Body 55 0.61 Blood 38 7.1* ↵* This is accumulated activity concentration (7.1 kBq h/MBq/g) in blood as actual blood dose is complicated by various blood vessel sizes.
NA = not available as uptake in liver typically increased during 6-d imaging period.
Organ Teff (h) Uptake at 168 h (MBq) Concentration at 168 h (kBq/g) Organ dose rate at 168 h (cGy/h) PBSC dose (cGy) Liver 64 65 36 1.9 8.3 Spleen 58 4.0 27 1.4 0.82 Kidneys 60 5.4 18 0.94 0.78 Lungs 42 6.1 5.1 0.27 1.2 Red marrow 55 24 21 0.69 29 Bone 64 29 5.2 0.58 0.48 Cortical bone 64 11 2.5 Trabecular bone 64 18 16 Total blood 31 27 4.9 Remainder of blood 31 19 4.9 0.25 4.9 Total body 55 240 0.0033 Remainder of body 46 100 0.0016 Remainder of body, no blood 49 83 1.4 To illustrate the computing process, uptake in cortical bone, trabecular bone, total blood, total body, remainder of body, and remainder of body without blood was listed but was not needed for organ dose rate and PBSC dose.
