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Journal of Nuclear Medicine

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OtherBasic Science Investigations

Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 1: Effects of Solvent on the Degradation of Radiohalogenation Precursors by 211At α-Particles

Oscar R. Pozzi and Michael R. Zalutsky
Journal of Nuclear Medicine April 2005, 46 (4) 700-706;
Oscar R. Pozzi
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Michael R. Zalutsky
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  • FIGURE 1.
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    FIGURE 1.

    Normal-phase HPLC profile of BuSTB radiohalogenation precursor after exposure to 211At at doses of 644, 1,658, and 4,157 Gy, as well as control (0 Gy).

  • FIGURE 2.
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    FIGURE 2.

    Radiolytic decomposition of BuSTB and MeSTB in chloroform and generation of a cold byproduct as a function of radiation dose.

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    FIGURE 3.

    Radiolytic decomposition of BuSTB and MeSTB in methanol under acidic conditions as a function of radiation dose.

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    FIGURE 4.

    Radiolytic decomposition of BuSTB and MeSTB in benzene under acidic conditions as a function of radiation dose.

  • FIGURE 5.
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    FIGURE 5.

    Calculated number of Cl atom radicals produced in chloroform by radiolysis as a function of radiation dose.

  • FIGURE 6.
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    FIGURE 6.

    Kinetics of radiolytic decomposition of BuSTB in chloroform: experimental data and fitted first-order equation [BuSTB] = [BuSTB]0e−k1t.

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    TABLE 1

    Radiolytic Degradation of Tin Precursors in Methanol in Presence and Absence of Acetic Acid

    PrecursorWith acetic acidWithout acetic acid
    Dose (Gy)% RemainingDose (Gy)% Remaining
    BuSTB1,72099.7 ± 2.01,84086.4 ± 1.7
    4,89097.9 ± 2.04,63080.2 ± 1.6
    MeSTB1,55099.7 ± 1.51,66096.3 ± 1.4
    5,59084.9 ± 1.35,92072.5 ± 1.1
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Journal of Nuclear Medicine: 46 (4)
Journal of Nuclear Medicine
Vol. 46, Issue 4
April 1, 2005
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Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 1: Effects of Solvent on the Degradation of Radiohalogenation Precursors by 211At α-Particles
Oscar R. Pozzi, Michael R. Zalutsky
Journal of Nuclear Medicine Apr 2005, 46 (4) 700-706;

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Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 1: Effects of Solvent on the Degradation of Radiohalogenation Precursors by 211At α-Particles
Oscar R. Pozzi, Michael R. Zalutsky
Journal of Nuclear Medicine Apr 2005, 46 (4) 700-706;
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Cited By...

  • Direct Procedure for the Production of 211At-Labeled Antibodies with an {varepsilon}-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugate
  • Radiopharmaceutical Chemistry of Targeted Radiotherapeutics, Part 3: {alpha}-Particle-Induced Radiolytic Effects on the Chemical Behavior of 211At
  • Potential and Pitfalls of Therapy with {alpha}-Particles
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