Article Figures & Data
Figures
- FIGURE 1.
Flowchart of patients enrolled in this study. FP = false-positive LN = lymph node MLN = mediastinal lymph node TP = true-positive.
- FIGURE 2.
18F-FDG PET and MRI scans of 42-y-old male NPC patient (undifferentiated cell type) with initial clinical stage of T1 N3b M0. Result of whole-body bone scan was negative (A). Unexpected L1–2 spine metastatic lesion was found on whole-body 18F-FDG PET scan (B, arrow) and later confirmed by MRI (C, arrow).
- FIGURE 3.
18F-FDG PET and CT scans of 29-y-old male NPC patient (poorly differentiated squamous cell type) with initial clinical stage of T3 N1 M0. Initial 18F-FDG PET scan showed huge tumor in nasopharyngeal roof, with metastases to lymph nodes in left upper and lower neck. No definite evidence of mediastinal lymph node metastasis was noted (A). Three months after definitive concurrent chemoradiotherapy, follow-up 18F-FDG PET showed complete remission of primary and metastatic lesions in left neck. However, equivocal mediastinal lymph node metastatic lesions were noted on both 18F-FDG PET scans and chest CT scans (B and C). Further follow-up 18F-FDG PET scans and chest CT scans showed no evidence of lymphadenopathy in mediastinal region (D and E). Findings shown in B can therefore be considered false-positive after concurrent chemoradiotherapy.
Tables
- TABLE 1
Comparison of Demographics and Disease Characteristics Between Primary NPC Patients With Distant Metastasis and Their Counterparts Without Distant Metastasis
Characteristic Patients with distant metastasis (n = 14) Patients without distant metastasis (n = 104) All patients (n = 118) P Age (y) 53.07 ± 11.66 49.22 ± 12.8 49.68 ± 12.68 0.288* Sex 0.221† Male 12 68 80 Female 2 36 38 Cell type (n = 91)§ 1.000† Nonkeratinized or poorly differentiated carcinoma 5 36 41 Undifferentiated carcinoma 9 68 77 Tumor stage 0.923‡ T1–2 8 58 66 T3–4 6 46 52 Nodal stage 0.044† N1 or less 2 45 47 N2 or greater 12 59 71 0.008† N2 or less 8 92 100 N3 6 12 18 - TABLE 2
Comparison of Demographics and Disease Characteristics Between Relapsed NPC Patients With Distant Metastasis and Their Counterparts Without Distant Metastasis
Characteristic Patients with distant metastasis (n = 4) Patients without distant metastasis (n = 18) All patients (n = 22) P Age (y) 45.0 ± 8.87 48.72 ± 8.68 48.05 ± 8.62 0.448* Sex 0.535† Male 4 13 17 Female 0 5 5 Cell type 0.586† Nonkeratinized or poorly differentiated carcinoma 3 8 11 Undifferentiated carcinoma 1 10 11 Initial tumor stage 0.582† T1–2 1 8 9 T3–4 3 7 10 Initial nodal stage 0.616† N1 or less 3 10 13 N2 or greater 1 8 9
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