OtherClinical Investigations

Rapid Scanning Protocol for Brain 18F-FDG PET: A Validation Study

Wei Ping Chen, Ichiro Matsunari, Akihiro Noda, Daisuke Yanase, Kazuyoshi Yajima, Nozomi Takeda, Masahito Yamada, Satoshi Minoshima and Shintaro Nishimura
Journal of Nuclear Medicine October 2005, 46 (10) 1633-1641;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Schematic representation of rapid and conventional scanning protocols.

  • FIGURE 2.
    FIGURE 2.

    Kinetic model used in simulation study. BBB = blood–brain barrier; 18F-FDG-6-P = 18F-FDG-6-phosphate.

  • FIGURE 3.
    FIGURE 3.

    (A) Comparison of normalized values between the 2 scanning protocols in healthy group. (B) Comparison of z values between the 2 scanning protocols in patient group. Error bars show SD of normalized values or z values in each scanning protocol. ACING = anterior cingulate gyrus; CBL = cerebellar hemisphere; FRT = frontal cortex; MFRT = medial frontal association cortex; MPRT = medial parietal association cortex; OCT = occipital cortex; PCING = posterior cingulate gyrus; PNS = pons; PRT = parietal cortex; SMC = primary sensorimotor cortex; TMP = temporal cortex; VC = primary visual cortex; VER = cerebellar vermis.

  • FIGURE 4.
    FIGURE 4.

    (A and B) Mean normalized activity and CV images obtained from conventional (A) and rapid (B) scanning protocols in healthy group. (C) z (rapid − conventional) images showing differences between the 2 protocols.

  • FIGURE 5.
    FIGURE 5.

    (A and B) Mean z image and CV images obtained from conventional (A) and rapid (B) scanning protocols in patient group. z (1 case) are z images of 1 patient with probable AD. (C) z (rapid − conventional) image showing differences between the 2 protocols.

  • FIGURE 6.
    FIGURE 6.

    ROC curves obtained from conventional- and rapid-protocol images with large z values, indicative of true-positive cases in area of posterior cingulate gyri and precunei (A) and lateral parietal association cortex (B).

  • FIGURE 7.
    FIGURE 7.

    Simulated time–activity curves in each region (left) and calculated values corresponding to the 2 protocols, normalized by mean value of cortical regions (right). CAD = caudate; CBL = cerebellum; FRT = frontal cortex; OCT = occipital cortex; PRT = parietal cortex; THL = thalamus; TMP = temporal cortex.

Tables

  • TABLE 1

    Different Parameters Between the 2 Protocols

    ParameterConventionalRapid
    Time after injection40 min60 min
    Length of transmission scan10 min1 min
    Length of emission scan10 min3 min
    Attenuation correctionMeasuredSegmented
  • TABLE 2

    Comparison of Relative Glucose Activities in Healthy Subjects and Mean z Values in Patients Between the 2 Protocols

    RegionRelative value (mean ± SD)Difference (%)Mean z value (mean ± SD)Difference (%)
    Conventional protocolRapid protocolConventional protocolRapid protocol
    R frontal association cortex1.08 ± 0.031.09 ± 0.04−1.20.13 ± 0.450.10 ± 0.542.9
    L frontal association cortex1.08 ± 0.031.08 ± 0.03−0.20.14 ± 0.500.11 ± 0.533.3
    R parietal association cortex1.13 ± 0.041.15 ± 0.04−1.8*1.19 ± 0.961.17 ± 1.052.1
    L parietal association cortex1.13 ± 0.041.14 ± 0.05−0.61.00 ± 0.701.01 ± 0.86−1.3
    R temporal association cortex1.03 ± 0.031.04 ± 0.03−0.40.53 ± 0.890.47 ± 1.025.7
    L temporal association cortex1.02 ± 0.031.01 ± 0.030.80.32 ± 0.590.46 ± 0.68−14.2
    R occipital association cortex1.16 ± 0.051.16 ± 0.050.50.30 ± 0.820.40 ± 0.92−10.5
    L occipital association cortex1.15 ± 0.051.13 ± 0.051.7*0.22 ± 0.610.35 ± 0.67−13.20
    R medial frontal cortex1.01 ± 0.031.01 ± 0.030.3−0.26 ± 0.34−0.25 ± 0.43−0.6
    L medial frontal cortex1.01 ± 0.021.00 ± 0.030.2−0.31 ± 0.61−0.24 ± 0.72−6.9
    R medial parietal cortex1.17 ± 0.061.17 ± 0.06−0.30.52 ± 0.910.43 ± 0.798.9
    L medial parietal cortex1.18 ± 0.051.19 ± 0.06−1.00.46 ± 0.690.36 ± 0.699.5
    R primary sensorimotor cortex1.14 ± 0.041.15 ± 0.05−1.20.60 ± 0.590.60 ± 0.61−0.7
    L primary sensorimotor cortex1.14 ± 0.031.14 ± 0.041.30.53 ± 0.610.54 ± 0.63−1.5
    R primary visual cortex1.19 ± 0.061.18 ± 0.071.2−0.20 ± 0.72−0.23 ± 0.733.9
    L primary visual cortex1.17 ± 0.061.17 ± 0.070.2−0.39 ± 0.74−0.40 ± 0.761.0
    R anterior cingulate gyrus0.82 ± 0.060.83 ± 0.06−0.70.25 ± 0.630.24 ± 0.601.7
    L anterior cingulate gyrus0.82 ± 0.060.83 ± 0.06−0.70.19 ± 0.590.16 ± 0.634.0
    R posterior cingulate gyrus1.04 ± 0.051.06 ± 0.05−2.0*1.04 ± 0.481.01 ± 0.442.6
    L posterior cingulate gyrus1.04 ± 0.051.06 ± 0.06−2.1*0.99 ± 0.510.96 ± 0.583.9
    R cerebellar hemisphere0.95 ± 0.060.93 ± 0.072.1−0.94 ± 0.65−0.81 ± 0.76−12.9
    L cerebellar hemisphere0.96 ± 0.060.93 ± 0.072.3−0.97 ± 0.72−0.78 ± 0.68−18.2
    R cerebellar vermis0.95 ± 0.060.94 ± 0.060.7−0.74 ± 0.52−0.71 ± 0.53−2.9
    L cerebellar vermis0.96 ± 0.050.95 ± 0.061.4−0.86 ± 0.62−0.79 ± 0.55−7.1
    Pons0.75 ± 0.040.74 ± 0.061.4−0.81 ± 0.68−0.96 ± 0.7415.3

    • ↵* P < 0.05, by post hoc Scheffé test followed by repeated-measures ANOVA.

    • Relative values = region/global brain.

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