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Journal of Nuclear Medicine

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OtherClinical Investigations

In Vivo Measurement of Brain Monoamine Oxidase B Occupancy by Rasagiline, Using 11C-l-Deprenyl and PET

Nanette M.T. Freedman, Eyal Mishani, Yodphat Krausz, Jolie Weininger, Hava Lester, Eran Blaugrund, Daphna Ehrlich and Roland Chisin
Journal of Nuclear Medicine October 2005, 46 (10) 1618-1624;
Nanette M.T. Freedman
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Eyal Mishani
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Yodphat Krausz
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Jolie Weininger
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Hava Lester
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Eran Blaugrund
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Daphna Ehrlich
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Roland Chisin
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  • FIGURE 1.
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    FIGURE 1.

    Summary of 11C-l-deprenyl images: average activity distribution for all 3 subjects in 1 image slice on each of the 4 scans—before (scan 1), immediately after (scan 2), and 2–3 (scan 3) and 4–6 wk (scan 4) after treatment with rasagiline. Color on all images is adjusted to same absolute scale of intensities.

  • FIGURE 2.
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    FIGURE 2.

    Comparison of 11C-l-deprenyl activity concentrations (30–70 min after injection) in brain regions on scans 1–4 (average over 3 subjects). Cortex includes frontal, occipital, parietal, and temporal cortices. Error bars indicate ±1 SD.

  • FIGURE 3.
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    FIGURE 3.

    11C activity concentrations (expressed as percentage injected dose [%ID] × 1,000/g) in whole-blood samples taken 30 min after injection during scans 1–4. Error bars indicate range of values.

  • FIGURE 4.
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    FIGURE 4.

    Average time–activity curves for basal ganglia (A), thalamus (B), cerebellum (C), and cortex (D) (including frontal, occipital, parietal, and temporal cortices) from 0 to 90 min after injection on scans 1–4.

  • FIGURE 5.
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    FIGURE 5.

    Comparison of modified Patlak slope ratios (relative to white matter) for brain regions on scans 1–4 (average over 3 subjects). Cortex includes frontal, occipital, parietal, and temporal cortices. Error bars indicate ±1 SD.

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Journal of Nuclear Medicine: 46 (10)
Journal of Nuclear Medicine
Vol. 46, Issue 10
October 1, 2005
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In Vivo Measurement of Brain Monoamine Oxidase B Occupancy by Rasagiline, Using 11C-l-Deprenyl and PET
Nanette M.T. Freedman, Eyal Mishani, Yodphat Krausz, Jolie Weininger, Hava Lester, Eran Blaugrund, Daphna Ehrlich, Roland Chisin
Journal of Nuclear Medicine Oct 2005, 46 (10) 1618-1624;

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In Vivo Measurement of Brain Monoamine Oxidase B Occupancy by Rasagiline, Using 11C-l-Deprenyl and PET
Nanette M.T. Freedman, Eyal Mishani, Yodphat Krausz, Jolie Weininger, Hava Lester, Eran Blaugrund, Daphna Ehrlich, Roland Chisin
Journal of Nuclear Medicine Oct 2005, 46 (10) 1618-1624;
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