Article Figures & Data
Figures
- FIGURE 1.
99mTc-TRODAT-1 SPECT images of 4 similarly aged individuals, 1 from each group: healthy subject (A), MSA-C patient (B), MSA-P patient (C), and PD control patient (D).
- FIGURE 2.
Bilateral putaminal uptakes (P/O ratios) of 99mTc-TRODAT-1 in 4 groups. Bilateral P/O ratios are significantly reduced in PD and MSA-P groups but are less reduced in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
- FIGURE 3.
Bilateral caudate nucleus uptakes (C/O ratios) of 99mTc-TRODAT-1 in 4 groups. Similar to findings for P/O ratios, bilateral C/O ratios are significantly reduced in PD and MSA-P groups but are only mildly reduced in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
- FIGURE 4.
Bilateral P/C ratios of 99mTc-TRODAT-1 in 4 groups. There is preferential involvement of putamen in PD and MSA-P groups, whereas P/C ratios for MSA-C are closer to those of healthy subjects. This indicates relatively diffuse involvement of both putamen and caudate nucleus in MSA-C group. Cont = contralateral; Ipsi = ipsilateral.
Tables
- TABLE 1
Clinical Information for 33 Healthy Control Subjects, 36 PD Patients, and 49 MSA Patients
Group n Sex* (F/M) Mean† Age (y) Disease duration (y) H&Y ADL‡ (%) UPDRS UPDRS-III§ Healthy control 33 17/16(52/48) 61.76 ± 8.77(46–75) — — — — — PD 36 16/20(44/56) 63.17 ± 7.48(45–75) 4.81 ± 3.49(1–17) 2.25 ± 0.86(1–4) 82.06 ± 11.75(50–100) 45.38 ± 22.28(3–93) 29.94 ± 14.20(2–62) MSA-C 19 10/9(53/47) 63.89 ± 6.56(47–73) 3.95 ± 2.46(1–11) 3.73 ± 1.19(2–5) 64.55 ± 15.08(40–90) 50.55 ± 19.77(18–84) 29.73 ± 12.99(9–53) MSA-P 30 18/12(60/40) 61.50 ± 7.92(46–75) 4.53 ± 3.28(1–15) 3.50 ± 1.33(1–5) 60.80 ± 18.47(30–90) 69.12 ± 23.20(24–123) 43.44 ± 14.59(16–79) Type of UR Mean uptake ± SD P value* Contralateral S/O Healthy control 0.87 ± 0.11 PD 0.31 ± 0.11 <0.0001 MSA-C 0.59 ± 0.23 <0.0001 <0.0001 MSA-P 0.33 ± 0.16 <0.0001 0.978 <0.0001 Contralateral C/O Healthy control 1.17 ± 0.16 PD 0.68 ± 0.20 <0.0001 MSA-C 0.90 ± 0.29 0.004 0.037 MSA-P 0.67 ± 0.27 <0.0001 0.998 0.05 Contralateral P/O Healthy control 0.73 ± 0.09 PD 0.17 ± 0.09 <0.0001 MSA-C 0.47 ± 0.22 <0.0001 <0.0001 MSA-P 0.20 ± 0.13 <0.0001 0.859 <0.0001 Contralateral P/C Healthy control 0.63 ± 0.05 PD 0.26 ± 0.11 <0.0001 MSA-C 0.51 ± 0.15 0.007 <0.0001 MSA-P 0.29 ± 0.10 <0.0001 0.888 <0.0001 Ipsilateral S/O Healthy control 0.87 ± 0.11 PD 0.42 ± 0.15 <0.0001 MSA-C 0.63 ± 0.23 0.002 0.006 MSA-P 0.37 ± 0.16 <0.0001 0.570 0.001 Ipsilateral C/O Healthy control 1.17 ± 0.15 PD 0.76 ± 0.21 <0.0001 MSA-C 0.93 ± 0.29 0.013 0.117 MSA-P 0.73 ± 0.27 <0.0001 0.962 0.081 Ipsilateral P/O Healthy control 0.74 ± 0.10 PD 0.29 ± 0.14 <0.0001 MSA-C 0.52 ± 0.23 0.003 0.003 MSA-P 0.24 ± 0.14 <0.001 0.370 <0.0001 Ipsilateral P/C Healthy control 0.63 ± 0.05 PD 0.39 ± 0.12 <0.0001 MSA-C 0.55 ± 0.15 0.198 0.004 MSA-P 0.32 ± 0.11 <0.0001 0.117 <0.0001 ↵* One-way ANOVA followed by comparisons using Games-Howell’s multiple comparisons.
