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OtherBasic Science Investigations

A PET Study After Treatment with an Anxiety-Provoking Agent, m-Chlorophenyl-Piperazine, in Conscious Rhesus Monkeys

Hiroyuki Takamatsu, Akihiro Noda, Yoshihiro Murakami, Mitsuyoshi Tatsumi, Rikiya Ichise and Shintaro Nishimura
Journal of Nuclear Medicine September 2003, 44 (9) 1516-1521;
Hiroyuki Takamatsu
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Akihiro Noda
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Yoshihiro Murakami
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Mitsuyoshi Tatsumi
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Rikiya Ichise
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Shintaro Nishimura
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  •   FIGURE 1.
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    FIGURE 1.

    Mean rCBF and rCMRglc images in control group and in groups treated with 0.2, 1.0, and 5.0 mg/kg mCPP and corresponding MR image.

  •   FIGURE 2.
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    FIGURE 2.

    rCBF changes after mCPP treatment of conscious rhesus monkeys. Control group data are standard data from our laboratory. Each column represents mean, and bars indicate SD. *P < 0.05 versus control group.

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    FIGURE 3.

    Changes in rCMRglc after mCPP treatment of conscious rhesus monkeys. Control group data are standard data from our laboratory. Each column represents mean, and bars indicate SD. *P < 0.05 versus control group.

  •   FIGURE 4.
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    FIGURE 4.

    Changes in plasma cortisol (A) and prolactin level (B) after mCPP treatment of conscious rhesus monkeys. Each symbol represents mean, and bars indicate SD. *P < 0.05 versus plasma cortisol and prolactin levels before mCPP treatment.

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    TABLE 1

    Physiologic Parameters After mCPP Treatments in Conscious Rhesus Monkeys

    ParameterBeforeTime after mCPP treatment (min)
    20 min40 min70 min100 min
    0.2 mg/kg
     MABP (mm Hg)161 ± 4164 ± 7154 ± 5142 ± 15148 ± 7
     HR (beats/min)204 ± 13192 ± 17197 ± 19198 ± 20199 ± 16
     pH7.468 ± 0.0307.433 ± 0.0387.420 ± 0.0427.445 ± 0.0207.449 ± 0.007
     pO2 (mm Hg)99.8 ± 3.691.3 ± 3.791.3 ± 3.686.0 ± 4.085.9 ± 4.4
     pCO2 (mm Hg)31.6 ± 1.734.2 ± 2.034.6 ± 1.934.9 ± 1.835.7 ± 1.7
     Glucose (mg/dL)133.2 ± 22.9119.8 ± 14.3106.0 ± 11.494.2 ± 13.090.4 ± 12.9
    1.0 mg/kg
     MABP (mm Hg)150 ± 7149 ± 6147 ± 6148 ± 8146 ± 7
     HR (beats/min)191 ± 5180 ± 14180 ± 8177 ± 6181 ± 3
     pH7.487 ± 0.0097.405 ± 0.0177.451 ± 0.0067.451 ± 0.0057.446 ± 0.004
     pO2 (mm Hg)99.7 ± 4.893.2 ± 0.992.3 ± 1.7100.6 ± 2.798.5 ± 2.3
     pCO2 (mm Hg)32.2 ± 3.037.5 ± 1.536.2 ± 2.735.5 ± 0.936.8 ± 0.8
     Glucose (mg/dL)110.0 ± 27.092.2 ± 9.499.0 ± 21.084.8 ± 6.090.8 ± 4.6
    5.0 mg/kg
     MABP (mm Hg)156 ± 7157 ± 6147 ± 8146 ± 8145 ± 7
     HR (beats/min)196 ± 10181 ± 13178 ± 12179 ± 12192 ± 9
     pH7.471 ± 0.0177.459 ± 0.0307.464 ± 0.0097.437 ± 0.0067.424 ± 0.007
     pO2 (mm Hg)98.4 ± 4.893.1 ± 2.699.6 ± 2.7108.7 ± 4.9106.4 ± 4.8
     pCO2 (mm Hg)33.0 ± 3.340.6 ± 4.340.8 ± 4.637.2 ± 3.139.8 ± 3.1
     Glucose (mg/dL)101.5 ± 24.890.0 ± 10.891.0 ± 16.294.0 ± 13.0103.5 ± 12.9
    • MABP and HR = mean arterial blood pressure and heart rate, respectively.

    • Data represent mean ± SD (n = 5).

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Journal of Nuclear Medicine
Vol. 44, Issue 9
September 1, 2003
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A PET Study After Treatment with an Anxiety-Provoking Agent, m-Chlorophenyl-Piperazine, in Conscious Rhesus Monkeys
Hiroyuki Takamatsu, Akihiro Noda, Yoshihiro Murakami, Mitsuyoshi Tatsumi, Rikiya Ichise, Shintaro Nishimura
Journal of Nuclear Medicine Sep 2003, 44 (9) 1516-1521;

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A PET Study After Treatment with an Anxiety-Provoking Agent, m-Chlorophenyl-Piperazine, in Conscious Rhesus Monkeys
Hiroyuki Takamatsu, Akihiro Noda, Yoshihiro Murakami, Mitsuyoshi Tatsumi, Rikiya Ichise, Shintaro Nishimura
Journal of Nuclear Medicine Sep 2003, 44 (9) 1516-1521;
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