Article Figures & Data
Figures
- FIGURE 1.
Comparison of FD calculated for 99mTc-HMPAO CBF SPECT image and FD calculated for 18F-FDG PET image of 62-y-old woman who underwent examination for memory impairment. Horizontal axis shows natural logarithm of cutoff values, and vertical axis shows natural logarithm of number of voxels in area surrounded by contour obtained with radioactivity above cutoff value. Slope of regression line on this graph corresponds to FD. • = FD value for 18F-FDG PET image (y = −1.109x + 15.29; r = 0.988); ○ = FD value for 99mTc-HMPAO CBF SPECT image (y = −1.278x + 14.46; r = 0.995).
- FIGURE 2.
Scatter plots of FD data between 99mTc-HMPAO CBF SPECT and 18F-FDG PET images in VaD group. Spearman rank correlation analysis showed significant correlation between FDs of the 2 images (y = 0.902x + 0.211; r = 0.619; P < 0.01).
- FIGURE 3.
T2-weighted MR images (left), SPECT or PET images (center), and 3D-SSP images (right) of representative subjects from control and VaD groups. (A) Images of 70-y-old man from control group. His FD was 0.799, and his MMSE score was 29. (B) Images of 75-y-old man from VaD group. His FD was 1.151, and his MMSE score was 15. In VaD, T2-weighted MR images revealed multiple small, bilateral infarcts in basal ganglia (arrows), SPECT and PET images showed diffuse decrease in CBF, and 3D-SSP image showed reduction mainly confined to frontal region (arrowhead). T2WI = T2-weighted image.
- FIGURE 4.
Comparison of FD between control group (n = 20) and VaD group (n = 17). Mann-Whitney test showed significant difference in FD between the 2 groups (P < 0.0001). ▵ = 7 patients with VaD at MMSE score of less than 20. *P < 0.0001.
- FIGURE 5.
Representative 3D-SSP z score maps from patients with diffuse reduction of CBF and reduction mainly confined to frontal region of CBF. (A) Diffuse reduction of CBF (arrows) (patient 1). (B) Decrease in frontal region (arrowheads) (patient 8).
Tables
Variable Control group VaD group Subjects (n) 20 17 Sex (M:F) 9:11 6:11 Age (y) 62.9 ± 11.3 69.5 ± 8.5 MMSE 26.5 ± 2.6 18.6 ± 4.5 Values are mean ± SD.
Patient no. Age (y) Sex FD MMSE Decreased CBF 1 57 M 0.912 23 Diffuse 2 82 F 1.199 20 Frontal 3 67 F 1.029 19 Diffuse 4 67 F 1.373 10 Frontal 5 74 F 1.108 21 Diffuse 6 69 F 0.963 21 Diffuse 7 69 F 0.835 22 Diffuse 8 75 M 1.151 15 Frontal 9 87 M 1.307 11 Diffuse 10 55 F 0.916 22 Diffuse 11 64 F 0.995 23 Diffuse 12 75 M 0.995 23 Diffuse 13 62 F 1.145 20 Diffuse 14 79 F 1.108 19 Frontal 15 63 F 1.042 21 Diffuse 16 66 M 1.307 10 Diffuse 17 71 M 1.199 17 Frontal
