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OtherBasic Science Investigations

High-Resolution Scintimammography: A Pilot Study

Rachel F. Brem, Joelle M. Schoonjans, Douglas A. Kieper, Stan Majewski, Steven Goodman and Cahid Civelek
Journal of Nuclear Medicine July 2002, 43 (7) 909-915;
Rachel F. Brem
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Joelle M. Schoonjans
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Douglas A. Kieper
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Stan Majewski
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Steven Goodman
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Cahid Civelek
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  • FIGURE 1.
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    FIGURE 1.

    Imaging using high-resolution breast-specific gamma camera in mediolateral projection (A), comparable with projection obtained with mammography, and craniocaudal projection (B).

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    FIGURE 2.

    Imaging using γ-isolation shield in craniocaudal (A) and mediolateral oblique (B) projections to reduce image contamination from extramammary radiotracer uptake and to apply mild compression.

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    FIGURE 3.

    Comparative resolution of traditional gamma camera using high-resolution (HR), high-efficiency collimators and breast-specific gamma camera. y-axis = resolution (mm).

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    FIGURE 4.

    Detection of unsuspected cancer with high-resolution breast-specific gamma camera in 33-y-old woman 2 y after lumpectomy and radiation therapy for infiltrating ductal carcinoma of right breast. Area of architectural distortion appeared in right breast, for which scintimammography was performed. Mediolateral oblique (A) and craniocaudal (B) mammograms of left breast showed normal findings. Scintimammogram with high-resolution breast-specific gamma camera showed normal findings in right breast. However, images of left breast (C) showed focal area of radiotracer uptake in upper (arrow) outer (arrowhead) quadrant of left breast. (D) Images with conventional gamma camera showed possible minimal radiotracer uptake in superior left breast. Biopsy showed 4-mm infiltrating ductal carcinoma.

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    TABLE 1

    Comparison of General-Purpose Gamma Camera and High-Resolution, Breast-Specific Gamma Camera: Number of Lesions Detected

    CategoryGeneral-purpose cameraBreast-specific camera
    True-positive1822
    False-negative106
    True-negative2828
    False-positive22
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    TABLE 2

    Comparison of General-Purpose Gamma Camera and High-Resolution, Breast-Specific Gamma Camera: Sensitivity in Detecting Lesions of Various Sizes and Palpabilities

    CategoryGeneral-purpose cameraBreast-specific camera
    All lesions64% (18/28)79% (22/28)
    Lesions ≤ 1 cm47% (7/15)67% (10/15)
    Nonpalpable lesions56% (10/18)72% (13/18)
    Palpable lesions80% (8/10)90% (9/10)
    Lesions > 1 cm85% (11/13)92% (12/13)
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Journal of Nuclear Medicine
Vol. 43, Issue 7
July 1, 2002
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High-Resolution Scintimammography: A Pilot Study
Rachel F. Brem, Joelle M. Schoonjans, Douglas A. Kieper, Stan Majewski, Steven Goodman, Cahid Civelek
Journal of Nuclear Medicine Jul 2002, 43 (7) 909-915;

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High-Resolution Scintimammography: A Pilot Study
Rachel F. Brem, Joelle M. Schoonjans, Douglas A. Kieper, Stan Majewski, Steven Goodman, Cahid Civelek
Journal of Nuclear Medicine Jul 2002, 43 (7) 909-915;
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  • Update on Emerging Technologies in Breast Imaging
  • Breast-specific gamma imaging as an adjunct modality for the diagnosis of invasive breast cancer with correlation to tumour size and grade
  • Is There a Clinical Role for Scintimammography in Breast Cancer Diagnosis?
  • Scintimammography with Dedicated Breast Camera Detects and Localizes Occult Carcinoma
  • Evaluation of a Small Cadmium Zinc Telluride Detector for Scintimammography
  • Invited Commentary: One Step Forward
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