Article Figures & Data
Figures
- FIGURE 1.
Dynamic imaging protocols used for 18F-FETNIM PET dosimetric study. Protocol 1 was used specifically to measure source organ uptake in thorax and abdomen. Protocols 2 and 3 were used in head and neck cancer patients. Frame rates varied in 3 protocols and are explained in text. Tr = transmission scan.
- FIGURE 2.
Activity of 18F-FETNIM in 4 source organs shows clearly higher activity than rest of body: blood, spleen, liver, and kidneys. Solid line is mean curve of individual values. Activity has been normalized to 1-MBq injected dose and 70-kg body weight. Similar shape in curves for blood, liver, and spleen indicates that blood activity has major impact on dose of 2 parenchymal organs.
- FIGURE 3.
Activity of 18F-FETNIM in source organs shows relatively low activity: muscle, brain, bone marrow, and lung. Solid line is mean curve of individual values. Activity has been normalized to 1-MBq injected dose and 70-kg body weight.
- FIGURE 4.
18F-FETNIM urine activity. Fitted curve is based on 28 samples from 27 patients. Note high percentage of total injected activity excreted in bladder for subjects holding urine. ID = injected dose.
Tables
Source organ Time (h) No. of patients Brain 0.023 3 Stomach 0.009 2 Upper large intestine 0.012 3 Heart contents 0.011 20 Kidneys 0.033 4 Liver 0.152 6 Lungs 0.015 7 Muscle 1.060 6 Pancreas 0.006 2 Red marrow 0.053 4 Spleen 0.013 6 Urinary bladder content 2 h 0.110 27 Urinary bladder content 4 h 0.244 27 Rest of body 2 h 0.795 Rest of body 4 h 0.760 Target organ Voiding interval 18F-FMISO* 2 h (mGy/MBq) 18F-FDG 2 h (mGy/MBq) 4 h (mGy/MBq) ICRP 60† (mGy/MBq) MIRD 19‡ (mGy/MBq) Adrenals 0.012 0.012 0.017 0.012 Brain 0.006 0.006 0.009 0.028 0.046 Breasts 0.007 0.007 0.012 0.009 Gallbladder wall 0.014 0.014 0.015 0.012 Lower large intestine wall 0.012 0.014 0.014 0.015 Small intestine 0.012 0.012 0.011 0.013 Stomach 0.012 0.012 0.013 0.011 Upper large intestine wall 0.014 0.015 0.014 0.012 Heart wall 0.011 0.011 0.019 0.062 0.068 Kidneys 0.027 0.027 0.016 0.021 0.021 Liver 0.024 0.024 0.018 0.011 0.024 Lungs 0.008 0.008 0.010 0.010 0.015 Muscle 0.012 0.012 0.014 0.011 Ovaries 0.013 0.014 0.018 0.015 0.011 Pancreas 0.019 0.019 0.017 0.012 0.014 Red marrow 0.012 0.012 0.010 0.011 0.011 Bone surfaces 0.011 0.011 0.008 0.011 Skin 0.007 0.007 0.005 0.008 Spleen 0.020 0.020 0.016 0.011 0.015 Testes 0.010 0.011 0.015 0.012 0.011 Thymus 0.009 0.009 0.016 0.011 Thyroid 0.009 0.009 0.015 0.010 Urinary bladder wall 0.062 0.127 0.021 0.160 0.073 Uterus 0.015 0.018 0.018 0.021 0.012 Total body 0.011 0.011 0.013 Effective dose equivalent§ 0.017 0.021 0.013 Effective dose§ 0.015 0.019 0.019
