OtherClinical Investigations

Comparison of Fatty Meal and Intravenous Cholecystokinin Infusion for Gallbladder Ejection Fraction

Gerbail T. Krishnamurthy and Paul H. Brown
Journal of Nuclear Medicine December 2002, 43 (12) 1603-1610;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Protocol used with CCK-8 and fatty meal study. Gallbladder was filled to full volume with 99mTc-HIDA during first 60 min of hepatic-phase imaging. Two doses of CCK-8 were infused sequentially for 10 min, beginning at 65 (CCK1) and 95 min (CCK2). Fatty meal was ingested in sitting position just before beginning gallbladder-phase data collection at 61 min in supine position.

  • FIGURE 2.
    FIGURE 2.

    Types of gallbladder emptying curves seen with fatty meal. Most common type of curve is represented by x; y curve shows no latent period because of cephalic phase (nervous control or sham feeding) of gallbladder emptying; x shows long latent period; and z shows short latent period. Curves w, x, and y show gallbladder in emptying phase when data collection was terminated at 60 min after meal.

  • FIGURE 3.
    FIGURE 3.

    GBEF obtained with CCK1, CCK2, and HHFM. Note that only 1 subject had GBEF < 60% with CCK1 and only 1 had < 50% with CCK2. GBEF values vary more with fatty meal.

  • FIGURE 4.
    FIGURE 4.

    Gallbladder EP seen with CCK1, CCK2, and HHFM. Note wider variability with HHFM than with CCK1 or CCK2.

  • FIGURE 5.
    FIGURE 5.

    Gallbladder ER (%GBEF/min) obtained with CCK1, CCK2, and fatty meal. Note that fatty meal produces lowest rate of emptying.

  • FIGURE 6.
    FIGURE 6.

    Percentile rank for HHFM-induced GBEF (A) and for CCK-8–induced GBEF (B). Note much smaller variation in GBEF with CCK-8 than with HHFM.

Tables

  • TABLE 1

    Gallbladder Ejection Fraction in 13 Healthy Subjects*

    Patient no.Age (y)SexCCK1CCK2Fatty meal
    EF (%)EP (min)ER (%/min)EF (%)EP (min)ER (%/min)EF (%)EP (min)ER (%/min)
    135M91.19.010.180.510.18.035.222.01.6
    227M88.28.011.088.910.08.938.042.20.9
    337M37.016.12.354.513.04.232.140.10.8
    453M96.018.15.385.219.84.391.841.72.2
    541M86.921.24.153.626.82.068.545.71.5
    624F61.99.46.659.49.06.645.150.10.9
    731F61.820.03.192.324.33.846.839.01.2
    831F70.214.05.068.910.06.962.023.02.7
    925F90.715.95.786.714.06.252.034.71.5
    1045F74.89.08.335.810.83.385.723.23.7
    1141F67.710.06.880.68.010.123.529.40.8
    1242F77.314.15.582.315.05.558.314.93.9
    1342F81.814.95.558.86.09.857.644.31.3
    Mean75.813.86.171.313.66.153.634.61.8
    SD16.34.42.517.46.42.620.211.01.1

    • ↵* Obtained with two 10-min infusions of 3 ng/kg/min CCK-8 or 240-mL (8 oz) fatty meal (half-and-half milk) per 70 kg of body weight.

  • TABLE 2

    Nutrient Content and Total Calories of Half-and-Half Milk in 6 U.S. Cities

    Nutrient content/30 mLCity and State (Brand)
    Portland, OR (Alpenrose)New York, NY (America Choice)Detroit, MI (CF-Berger)Jackson, MS (DairyFresh)Los Angeles, CA (Altadena)Miami, FL (McArthur Dairy)
    Total fat (g)3.03.03.03.53.03.0
    Cholesterol (mg)10.015.010.015.015.015.0
    Carbohydrate (g)1.01.01.01.01.01.0
    Protein (g)1.01.01.01.01.01.0
    Sodium (mg)10.020.010.020.015.015.0
    Total calories404035404040
Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools
Bookmark this article

Jump to section