Article Figures & Data
Figures
- FIGURE 1.
Radiochemical synthesis of [18F]FETNIM from 1-(2′-nitro-1′-imidazolyl)-2,3-O-isopropylidene-4-tosyloxybutane.
- FIGURE 2.
Typical chromatograms of rat and human tissues as detected by radio-TLC and digital autoradiography. Human plasma sample was analyzed at 30 min after injection of [18F]FETNIM, whereas rat tumor and liver samples were analyzed at 60 min. Radiochromatograms of rat and human plasma were qualitatively and quantitatively similar. arb. = arbitrary.
- FIGURE 3.
Relationship between percentage of unchanged [18F]FETNIM and uptake in DMBA-induced rat tumors. Poor correlation was observed at early times (A and B), but, at later time, significant inverse correlation was found (C).
Tables
Tissue 15 min (n = 3) 30 min (n = 3) 60 min (n = 4) 120 min (n = 7) 240 min (n = 3) Blood 0.325 ± 0.056 0.333 ± 0.056 0.206 ± 0.004 0.099 ± 0.024 0.053 ± 0.009 Plasma 0.313 ± 0.064 0.310 ± 0.047 0.155 ± 0.015* 0.080 ± 0.003† 0.030 ± 0.007 Heart 0.338 ± 0.084 0.359 ± 0.057 0.246 ± 0.011 0.134 ± 0.032 0.071 ± 0.010 Lung 0.357 ± 0.056 0.360 ± 0.053 0.246 ± 0.014 0.113 ± 0.028 0.057 ± 0.008 Liver 0.400 ± 0.100 0.478 ± 0.091 0.322 ± 0.011 0.168 ± 0.046 0.142 ± 0.043 Spleen 0.329 ± 0.088 0.338 ± 0.061 0.213 ± 0.007 0.102 ± 0.023 0.054 ± 0.010 Kidney 0.737 ± 0.069 1.200 ± 0.450 0.504 ± 0.024 0.397 ± 0.092 0.231 ± 0.041 Bladder 2.10 ± 1.70 1.67 ± 0.89 0.90 ± 0.29 0.73 ± 0.71 NA Urine 35 ± 11‡ NA NA 14 ± 5§ 18 ± 9 Adrenal gland 0.379 ± 0.074 0.480 ± 0.130 0.386 ± 0.094 0.177 ± 0.054 0.080 ± 0.002 Pancreas 0.246 ± 0.097 0.336 ± 0.059 0.186 ± 0.015 0.103 ± 0.022 0.063 ± 0.012 Intestine 0.330 ± 0.110 0.370 ± 0.065 0.360 ± 0.100 0.230 ± 0.150 0.129 ± 0.018 Stomach 0.320 ± 0.130 0.328 ± 0.038 0.370 ± 0.180 0.146 ± 0.036 NA Fat (subcutaneous) 0.045 ± 0.012 0.043 ± 0.015 0.035 ± 0.010 0.013 ± 0.004 0.010 ± 0.006 Muscle 0.263 ± 0.065 0.345 ± 0.048 0.242 ± 0.009 0.116 ± 0.023 0.061 ± 0.011 Ovary 0.400 ± 0.120 0.418 ± 0.085 0.255 ± 0.023 0.123 ± 0.021 NA Bone (skull) 0.054 ± 0.016 0.071 ± 0.009 0.058 ± 0.007 0.087 ± 0.052 0.025 ± 0.003 Marrow 0.480 ± 0.150 0.630 ± 0.270 0.372 ± 0.067 0.119 ± 0.038 NA Cerebellum 0.069 ± 0.029 0.103 ± 0.024 0.094 ± 0.016 0.063 ± 0.009 0.045 ± 0.004 Tumor 0.480 ± 0.10* 0.383 ± 0.096‡ 0.239 ± 0.037§ 0.178 ± 0.046∥ 0.087 ± 0.043¶ Ratio 15 min (n = 3) 30 min (n = 3) 60 min (n = 4) 120 min (n = 7) 240 min (n = 3) Tumor-to-blood 1.49 ± 0.40 1.15 ± 0.35 1.16 ± 0.18 1.79 ± 0.64 1.65 ± 0.87 Liver-to-blood 1.23 ± 0.37 1.44 ± 0.37 1.56 ± 0.06 1.69 ± 0.62 2.70 ± 0.94 Muscle-to-blood 0.81 ± 0.24 1.04 ± 0.23 1.17 ± 0.05 1.17 ± 0.37 1.16 ± 0.30 Tumor-to-muscle 1.84 ± 0.59 1.11 ± 0.32 0.99 ± 0.16 1.53 ± 0.50 1.42 ± 0.76 Data are mean ± SD.
Time (min) Plasma Liver Tumor % n % n % n 15 72 (66–78) 6 5.0 1 16 1 30 87 (85–88) 3 1.5 (0.6–2.3) 3 21 (3–45) 4 60 84 (83–86) 2 1.5 (0.6–2.3) 2 24 (9–49) 3 120 80 (77–84) 3 0.2 (0.0–1.0) 4 23 (6–71) 5 240 71 (69–74) 2 1.4 (0.0–2.3) 3 10 (5–14) 6 Data are mean (range).
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