Evaluation of Early-Stage Parkinson’s Disease with 99mTc-TRODAT-1 Imaging

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FIGURE 1.
^99mTc-TRODAT-1 SPECT in transverse views of healthy volunteer (A) and of patients with HYS stage I (B) and stage II (C) Parkinson’s disease. Asymmetric striatal uptake was observed, with more profound loss contralateral to symptoms or more affected limbs.
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FIGURE 2.
Specific striatal uptake of ^99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I and stage II Parkinson’s disease.
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FIGURE 3.
Specific putaminal uptake of ^99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I and stage II Parkinson’s disease.
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FIGURE 4.
Specific putaminal uptake of ^99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I Parkinson’s disease contralateral and ipsilateral to symptoms.
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FIGURE 5.
Specific putaminal uptake of ^99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage II Parkinson’s disease contralateral and ipsilateral to symptoms.
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FIGURE 6.
Specific posterior putaminal uptake of ^99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I Parkinson’s disease ipsilateral to symptoms.

TABLE 1

Specific Uptake of ^99mTc-TRODAT-1 in Striatum and Subregions in Patients with Early Parkinson’s Disease

Region	Healthy volunteers	Stage I Parkinson’s disease	Stage II Parkinson’s disease
Striatum	1.98 ± 0.24	1.62 ± 0.11*	1.22 ± 0.12*
Putamen
Total	1.81 ± 0.18	1.27 ± 0.14*	0.94 ± 0.20*
Contralateral		1.02 ± 0.20	0.73 ± 0.19
Ipsilateral		1.49 ± 0.22^†	1.14 ± 0.29^†
Caudate
Total	2.13 ± 0.31	1.97 ± 0.21	1.51 ± 0.17*
Contralateral		1.95 ± 0.22	1.45 ± 0.24
Ipsilateral		1.99 ± 0.34	1.58 ± 0.23‡

↵*P < 0.01 compared with volunteers or adjacent group.
↵^†P < 0.01 compared with volunteers or contralateral side.
↵^‡P < 0.01 compared with volunteers only.
Data are expressed as mean ± SD. Contralateral means side opposite to symptoms or more affected limbs. Ipsilateral means side of symptoms or more affected limbs.