Article Figures & Data
Figures
- FIGURE 1.
Combined CT–scintillation camera imaging system.
- FIGURE 2.
Overview of template projection reconstruction process.
- FIGURE 3.
Example of fused image available from combined CT–scintillation camera imaging system. CT image is shown along with spatially correlated SPECT image indicating 131I-MIBG uptake in lymph node in patient’s left axilla.
- FIGURE 4.
Anterior planar 131I-MIBG scans of three neuroblastoma patients. Patient 1 shows two separate lesions in abdomen along with normal liver uptake (left side of image) and excreted bladder activity (lower portion of image). Patient 2 shows one lesion in left clavicle and one near left axilla along with liver uptake (lower portion of image) and diffuse low-level background tissue uptake. Patient 3 shows two (faint) lesions in abdomen along with normal liver uptake (left side of image) and intense activity in large bowel.
- FIGURE 5.
Coregistered CT and reconstructed SPECT images of patient 1.
- FIGURE 6.
Coregistered CT and reconstructed SPECT images of patient 2.
- FIGURE 7.
Coregistered CT and reconstructed SPECT images of patient 3. In images on right, central focus is small lesion that does not appear to anatomically correspond to left adrenal; left focus is part of large lesion; and right focus is part of bowel uptake.
Tables
- TABLE 1.
Tumor Volume Measurement Results for Three Patients Using Different Measurement Methods
Patient no. Method* CT (mL) CV MVOI LS TC WLS No coll W/coll ML FBP ML FBP Patient 1 Large 48.5 1.77 0.440 0.914 1.22 1.22 1.59 1.54 1.29 Small 2.1 0.67 0.135 0.254 1.27 0.98 3.34 2.89 0.400 Patient 2 Large 12.7 0.318 0.0770 0.255 0.335 0.327 0.470 0.429 0.329 Small 0.67 2.57 0.0992 0.370 3.625 3.50 6.845 5.11 3.922 Patient 3 Large 117 0.0348 0.0433 0.0614 0.0681 0.0755 0.147 0.139 0.0722 Small 1.3 0.705 0.0592 0.148 1.53 1.75 3.13 2.94 1.132 ↵* Measurements in MBq/mL unless otherwise noted.
CV = standard conjugate views; MVOI = mean volume of interest, with and without compensation for collimator (coll); LS = least-squares fitting with reconstructed SPECT data and templates; TC = template correction with reconstructed SPECT data and templates; WLS = planar weighted least-squares fitting using planar emission data and projected templates; ML = maximum-likelihood expectation maximization reconstruction; FBP = filtered backprojection reconstruction.
- TABLE 2.
Comparison of CT-Derived Tumor Volumes for Separate CT Scans and Analyses of Patients
Patient no. Our CT-defined volume (mL) Independent CT-defined volume (mL) 1 48.5 63.4 2 12.7 13.3 3 116.8 85.7
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