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OtherBASIC SCIENCE INVESTIGATIONS

Effect of Protein Binding on Renal Extraction of 131I-OIH and 99mTc-Labeled Tubular Agents

Dennis Eshima, Lorie Eshima, Lory Hansen, Malgorzata Lipowska, Luigi G. Marzilli and Andrew Taylor
Journal of Nuclear Medicine December 2000, 41 (12) 2077-2082;
Dennis Eshima
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Lorie Eshima
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Lory Hansen
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Malgorzata Lipowska
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Luigi G. Marzilli
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Andrew Taylor Jr
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    TABLE 1.

    Protein Binding (%) of 131I-OIH, 99mTc-MAG3, and ll-, dd-, and dl-EC in Isolated Rat Kidney Perfusates Containing Albumin and Dextran

    AgentAlbuminDextran (2.5 g/dL)
    2.5 g/dL7.5 g/dL
    MAG386.8 ± 1.095.1 ± 0.10
    OIH51.9 ± 2.780.9 ± 0.10
    dd-EC25.8 ± 1.030.3 ± 0.81.9 ± 0.9 
    OIH63.0 ± 2.176.7 ± 0.21.7 ± 1.2 
    dl-EC27.8 ± 1.034.2 ± 0.80
    OIH61.9 ± 1.174.2 ± 0.50
    ll-EC20.2 ± 3.030.5 ± 1.90.2 ± 0.3 
    OIH55.6 ± 1.269.0 ± 0.80.6 ± 0.09
    • View popup
    TABLE 2.

    Isolated Rat Kidney EFs (%) of 131I-OIH, 99mTc-MAG3, and ll-, dd-, and dl-99mTc-EC from Perfusates Containing Albumin and Dextran

    AgentAlbuminDextran (2.5 g/dL)
    2.5 g/dL7.5 g/dL
    MAG343.9 ± 2.818.2 ± 3.163.6 ± 6.2
    OIH62.0 ± 4.721.4 ± 8.765.0 ± 4.2
     Ratio0.71 ± 0.060.98 ± 0.360.98 ± 0.06
    dd-EC77.1 ± 4.639.3 ± 10.061.6 ± 4.1
    OIH78.0 ± 5.429.8 ± 6.678.2 ± 4.2
     Ratio0.99 ± 0.071.31 ± 0.110.79 ± 0.05
    dl-EC59.7 ± 8.241.7 ± 13.752.0 ± 10.4
    OIH67.4 ± 7.228.6 ± 12.873.9 ± 6.4
     Ratio0.88 ± 0.041.54 ± 0.210.70 ± 0.10
    ll-EC56.7 ± 6.545.3 ± 4.746.2 ± 6.6
    OIH61.5 ± 7.529.4 ± 8.973.2 ± 9.1
     Ratio0.93 ± 0.081.67 ± 0.50.63 ± 0.04
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Journal of Nuclear Medicine
Vol. 41, Issue 12
December 1, 2000
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Effect of Protein Binding on Renal Extraction of 131I-OIH and 99mTc-Labeled Tubular Agents
Dennis Eshima, Lorie Eshima, Lory Hansen, Malgorzata Lipowska, Luigi G. Marzilli, Andrew Taylor
Journal of Nuclear Medicine Dec 2000, 41 (12) 2077-2082;

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Effect of Protein Binding on Renal Extraction of 131I-OIH and 99mTc-Labeled Tubular Agents
Dennis Eshima, Lorie Eshima, Lory Hansen, Malgorzata Lipowska, Luigi G. Marzilli, Andrew Taylor
Journal of Nuclear Medicine Dec 2000, 41 (12) 2077-2082;
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