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Tumor Cell Metabolism Imaging

¹ Department of Nuclear Medicine, University of Freiburg, Freiburg, Germany; and ² Department of Radiology, German Cancer Research Center, Heidelberg, Germany

Correspondence: For correspondence or reprints contact: Wolfgang. A. Weber, Department of Nuclear Medicine, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany. E-mail: Wolfgang.weber{at}uniklinik-freiburg.de

Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

Key Words: glucose metabolism • amino acid metabolism • lipid metabolism • PET • optical imaging • MRI

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