Abstract
242501
Introduction: The accurate assessment of inflammatory activity of the extraocular muscles (EOMs) in thyroid associated ophthalmopathy (TAO) is crucial for formulating subsequent treatment strategies and prognostic judgments. This study aims to explore the efficacy of using 68Ga-DOTATATE PET/CT to assess the inflammatory activity of EOMs in TAO patients.
Methods: This study enrolled 22 TAO patients and 6 volunteers, all of whom underwent 68Ga-DOTATATE PET/CT scans of the orbit. Among these, 18 patients also underwent orbital 99mTc-DTPA SPECT/CT within one week, and the other 4 patients received orbital MRI examinations. All imaging data were independently assessed, followed by comparative data analysis. The patients then received different treatment schemes, and their prognosis was followed up.
Results: 68Ga-DOTATATE PET/CT could effectively evaluate the inflammatory activity of the EOMs in TAO patients and demonstrate good consistency with 99mTc-DTPA SPECT/CT and orbital MRI. The receiver operating characteristic (ROC) curves for each EOM, treated as individual research units, exhibited an area under the curve (AUC) exceeding 0.9. Notably, the medial rectus demonstrated the highest involvement and diagnostic precision (AUC=0.976, P<0.001). Patients treated with glucocorticoids (GCs) showed significantly higher SUVmax in their EOMs compared to those receiving symptomatic treatment (P<0.01).
Conclusions: 68Ga-DOTATATE PET/CT is a reliable method for assessing the inflammatory activity of EOMs in TAO patients, providing strong objective evidence for the precise diagnosis and treatment.
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