Cerebral ¹⁸F-FDG PET/CT Metabolism as Diagnostic Signature for Central Nervous System Toxicity After Immune Checkpoint Blockade Cancer Treatment

1Department of Hepatobiliary and Pancreatic Surgery, Institute of Abdominal Surgery, Fujian Provincial Key Laboratory of Precision Medicine for Cancer, and Department of Hepatobiliary and Pancreatic Surgery, National Regional Medical Center Binhai Campus, First Affiliated Hospital of Fujian Medical University, Fuzhou, China;

2Department of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;

3State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China;

1Department of Hepatobiliary and Pancreatic Surgery, Institute of Abdominal Surgery, Fujian Provincial Key Laboratory of Precision Medicine for Cancer, and Department of Hepatobiliary and Pancreatic Surgery, National Regional Medical Center Binhai Campus, First Affiliated Hospital of Fujian Medical University, Fuzhou, China;

4Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China;

5Department of General Surgery, Hainan Hospital of People’s Liberation Army General Hospital, Sanya, China;

6Department of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China;

7Faculty of Psychology, Institute of Educational Science, Huazhong University of Science and Technology, Wuhan, China;

8Department of Orthopedics and Spine Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, China;

9School of Public Health, Shantou University, Shantou, China;

10Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University, Beijing, China;

11Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou, China;

11Department of Pathology, Cancer Hospital of Shantou University Medical College, Shantou, China;

12Department of Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;

12Department of Clinical Laboratory, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;

13Acute Communicable Disease Epidemiology Division, Dallas County Health and Human Services, Dallas, Texas;

14Key Clinical Laboratory of Henan Province, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; and

4Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China;

8Department of Orthopedics and Spine Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, China;

15Department of Bone and Soft Tissue Oncology, Cancer Hospital of Shantou University Medical College, Shantou, China

3State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China;

6Department of Clinical Laboratory, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, Guangzhou, China;

1Department of Hepatobiliary and Pancreatic Surgery, Institute of Abdominal Surgery, Fujian Provincial Key Laboratory of Precision Medicine for Cancer, and Department of Hepatobiliary and Pancreatic Surgery, National Regional Medical Center Binhai Campus, First Affiliated Hospital of Fujian Medical University, Fuzhou, China;