Article Figures & Data
Figures
- FIGURE 1.
Immunohistochemical images of CD105 staining of microvessels in UIP (A and B) and non-UIP (C and D) at ×200 magnification (digital-based platform).
- FIGURE 2.
Representative participant [18F]FDG PET/CT scans showing high (A) and low (B) TBR of [18F]FDG uptake. Immunohistochemistry images of stained patient biopsies show high (C) and low (D) expression of CD105/endoglin (arrowheads).
- FIGURE 3.
Box plot highlighting increased distribution of CD105 in UIP vs. non-UIP histology (P = 0.011). *Patient 6 outlier (CD105 = 44). fLD = fibrotic lung disease.
- FIGURE 4.
Kaplan–Meier survival curve showing how neoangiogenic marker CD105 predicts overall survival (P = 0.041).
- FIGURE 5.
Kaplan–Meier survival curve showing how vasculature marker CD31 predicts overall survival (P = 0.014).
- FIGURE 6.
Scatterplot demonstrating positive correlation (Spearman rank correlation, 0.556; P < 0.05) between CD105 and [18F]FDG uptake (TBR).
Tables
- TABLE 1.
Participant Characteristics, Immunohistochemistry Results, and [18F]FDG PET/CT Quantification*
Patient Forced vital capacity prediction (%) Transfer factor of lung for carbon monoxide prediction (%) Histology Treatment for ILD CD105 (Va%/hpf) CD31 (Va%/hpf) GLUT-1 macrophage score TBR CD80 average of hpf counts CD163 average of hpf counts CD163:CD80 ratio 1 65 57 UIP No 22 26 0 5.29 42.5 57.5 1.35 2 54 27 NSIP No 19 23 1 7.71 NA NA NA 3 47 33 OP No 10 15 1 3 NA NA NA 4 57 29 NSIP No 10 34 0 4.6 16.5 75 4.55 5 99 79 UIP No 23 30 0 4.29 9.5 34 3.58 6 73 41 UIP No 44 NA 0 4.67 1.5 31.5 21 7 NA 45 UIP No NA NA 2 6 2.5 58.5 23.4 8 95 64 UIP No 18 38 0 3.86 32.5 52.5 1.62 9 91 66 NSIP No NA 29 1 5.29 33 36 1.09 10 77 47 NSIP No 14 NA 0 3.33 20.5 51 2.49 11 104 70 UIP No 25 NA 1 4.6 4.5 85 18.89 12 99 63 UIP No 34 70 0 5.86 18.5 65 3.51 13 75 54 UIP No 17 21 0 3.75 10.5 56 5.33 14 99 NA UIP No NA 55 2 6.33 7.5 31.5 4.2 15 43 43 UIP No NA 45 0 5.17 3 51.5 17.17 16 63 63 UIP No 24 35 0 10.29 1 42.5 42.5 17 NA NA UIP No NA NA 2 6.17 NA NA NA 18 58 40 UIP No 19 45 1 12 11.5 38 3.3 ↵* Lung function results were within 10 d of [18F]FDG PET/CT scan.
NSIP = nonspecific interstitial pneumonia; NA = not available; OP = organizing pneumonia.
