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Research ArticleClinical Investigation

The Impact of Baseline PSMA PET/CT Versus CT on Outcomes of 223Ra Therapy in Metastatic Castration-Resistant Prostate Cancer Patients

Dianne Bosch, Kim J.M. van der Velden, Irma M. Oving, Dirk N.J. Wyndaele, Leo E. Weijs, W. Dick van Schelven, Wim J.G. Oyen, Erik T. te Beek, Addy C.M. van de Luijtgaarden, Diederik M. Somford, James Nagarajah, Rick Hermsen, Niven Mehra, Winald R. Gerritsen, Maarten J. van der Doelen and Inge M. van Oort
Journal of Nuclear Medicine April 2024, 65 (4) 541-547; DOI: https://doi.org/10.2967/jnumed.123.266654
Dianne Bosch
1Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands;
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Kim J.M. van der Velden
1Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands;
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Irma M. Oving
2Department of Medical Oncology, Ziekenhuisgroep Twente, Almelo, The Netherlands;
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Dirk N.J. Wyndaele
3Department of Nuclear Medicine, Catharina Hospital, Eindhoven, The Netherlands;
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Leo E. Weijs
4Department of Radiology and Nuclear Medicine, Ziekenhuisgroep Twente, Almelo, Netherlands;
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W. Dick van Schelven
5Department of Nuclear Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands;
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Wim J.G. Oyen
6Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands;
7Department of Biomedical Sciences, Humanitas University, Milan, Italy;
8Department of Nuclear Medicine, Humanitas Clinical and Research Center, Milan, Italy;
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Erik T. te Beek
9Department of Nuclear Medicine, Reinier de Graaf Gasthuis, Delft, The Netherlands;
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Addy C.M. van de Luijtgaarden
10Department of Medical Oncology, Reinier de G raaf Gasthuis and Reinier Haga Prostate Cancer Center, Delft, The Netherlands;
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Diederik M. Somford
11Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands;
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James Nagarajah
12Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands;
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Rick Hermsen
13Department of Nuclear Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; and
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Niven Mehra
14Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
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Winald R. Gerritsen
14Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
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Maarten J. van der Doelen
1Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands;
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Inge M. van Oort
1Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands;
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Article Information

vol. 65 no. 4 541-547
DOI 
https://doi.org/10.2967/jnumed.123.266654
PubMed 
38423781

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 10, 2023
  • Revision received January 5, 2024
  • Published online April 1, 2024.

Article Versions

  • previous version (February 29, 2024 - 10:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Dianne Bosch*,1,
  2. Kim J.M. van der Velden*,1,
  3. Irma M. Oving2,
  4. Dirk N.J. Wyndaele3,
  5. Leo E. Weijs4,
  6. W. Dick van Schelven5,
  7. Wim J.G. Oyen6,7,8,
  8. Erik T. te Beek9,
  9. Addy C.M. van de Luijtgaarden10,
  10. Diederik M. Somford11,
  11. James Nagarajah12,
  12. Rick Hermsen13,
  13. Niven Mehra14,
  14. Winald R. Gerritsen14,
  15. Maarten J. van der Doelen1 and
  16. Inge M. van Oort1
  1. 1Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands;
  2. 2Department of Medical Oncology, Ziekenhuisgroep Twente, Almelo, The Netherlands;
  3. 3Department of Nuclear Medicine, Catharina Hospital, Eindhoven, The Netherlands;
  4. 4Department of Radiology and Nuclear Medicine, Ziekenhuisgroep Twente, Almelo, Netherlands;
  5. 5Department of Nuclear Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands;
  6. 6Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands;
  7. 7Department of Biomedical Sciences, Humanitas University, Milan, Italy;
  8. 8Department of Nuclear Medicine, Humanitas Clinical and Research Center, Milan, Italy;
  9. 9Department of Nuclear Medicine, Reinier de Graaf Gasthuis, Delft, The Netherlands;
  10. 10Department of Medical Oncology, Reinier de G raaf Gasthuis and Reinier Haga Prostate Cancer Center, Delft, The Netherlands;
  11. 11Department of Urology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands;
  12. 12Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands;
  13. 13Department of Nuclear Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands; and
  14. 14Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
  1. For correspondence or reprints, contact Maarten J. van der Doelen (maarten.vanderdoelen{at}radboudumc.nl).
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Journal of Nuclear Medicine: 65 (4)
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The Impact of Baseline PSMA PET/CT Versus CT on Outcomes of 223Ra Therapy in Metastatic Castration-Resistant Prostate Cancer Patients
Dianne Bosch, Kim J.M. van der Velden, Irma M. Oving, Dirk N.J. Wyndaele, Leo E. Weijs, W. Dick van Schelven, Wim J.G. Oyen, Erik T. te Beek, Addy C.M. van de Luijtgaarden, Diederik M. Somford, James Nagarajah, Rick Hermsen, Niven Mehra, Winald R. Gerritsen, Maarten J. van der Doelen, Inge M. van Oort
Journal of Nuclear Medicine Apr 2024, 65 (4) 541-547; DOI: 10.2967/jnumed.123.266654

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The Impact of Baseline PSMA PET/CT Versus CT on Outcomes of 223Ra Therapy in Metastatic Castration-Resistant Prostate Cancer Patients
Dianne Bosch, Kim J.M. van der Velden, Irma M. Oving, Dirk N.J. Wyndaele, Leo E. Weijs, W. Dick van Schelven, Wim J.G. Oyen, Erik T. te Beek, Addy C.M. van de Luijtgaarden, Diederik M. Somford, James Nagarajah, Rick Hermsen, Niven Mehra, Winald R. Gerritsen, Maarten J. van der Doelen, Inge M. van Oort
Journal of Nuclear Medicine Apr 2024, 65 (4) 541-547; DOI: 10.2967/jnumed.123.266654
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  • 177Lu-PSMA-617 Consolidation Therapy After Docetaxel in Patients with Synchronous High-Volume Metastatic Hormone-Sensitive Prostate Cancer: A Randomized, Phase 2 Trial
  • Transarterial Radioembolization in the TACOME Trial: Dosimetric Analysis and Clinical Features in Predicting Response and Overall Survival
  • Retreatment of Metastatic Castration-Resistant Prostate Cancer Patients with 223Ra Therapy in Daily Practice
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Keywords

  • 223Ra
  • computer tomography
  • castration-resistant prostate cancer
  • overall survival
  • PSMA PET/CT
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