Research ArticleClinical Investigation

Dynamic Human Brain Imaging with a Portable PET Camera: Comparison to a Standard Scanner

Elizabeth A. Bartlett, Mohammad Lesanpezeshki, Sergey Anishchenko, Ilia Shkolnik, R. Todd Ogden, J. John Mann, David Beylin, Jeffrey M. Miller and Francesca Zanderigo
Journal of Nuclear Medicine February 2024, 65 (2) 320-326; DOI: https://doi.org/10.2967/jnumed.122.265309

Article Figures & Data

Figures

  • Figure
  • FIGURE 1.
    FIGURE 1.

    CerePET shown in research setup used in this study.

  • FIGURE 2.
    FIGURE 2.

    Regionwise estimates of SUV, Ki, and CMRglu plotted for CerePET vs. Biograph mCT. All brain regions from FreeSurfer Desikan–Killiany and subcortical atlases are shown (listed in supplemental materials). SUB = subject.

  • FIGURE 3.
    FIGURE 3.

    Bland–Altman plots for SUV, Ki, and CMRglu for all participants (top) and excluding 1 participant with high Biograph mCT Ki and CMRglu values (bottom). Not considering this 1 participant yields diminished proportional bias. Means are shown as blue lines, 95% limits of agreement are shown as thin black lines, and regression lines are shown as thick black lines. SUB = subject.

  • FIGURE 4.
    FIGURE 4.

    Voxelwise maps for CerePET and Biograph mCT for SUV, Ki, and CMRglu. (A) Representative participant in participant MRI space. (B) Average maps across 20 healthy volunteers in Montreal Neurologic Institute space (left), and average absolute PD maps across 20 healthy volunteers (right). Color maps apply within outcome measures in A and B. (C) Statistical parametric mapping multiple-comparisons–corrected t-value maps showing single significant cluster with familywise error rate of P = 0.05 and cluster-size thresholds of 546 (SUV), 408 (Ki), and 410 voxels (CMRglu). t-val = t value.

Tables

  • TABLE 1.

    CerePET and Biograph mCT Performance Characteristics

    CharacteristicCerePETBiograph mCT (31)
    Crystal materialCerium-doped lutetium yttrium orthosilicateLutetium oxyorthosilicate
    Crystal pixel size2 × 2 × 13 mm4 × 4 × 20 mm
    DetectorsPhotomultiplier tubePhotomultiplier tube
    Axial FOV8.6 cm (stationary), 22.5 cm (translating)22.1 cm
    Transaxial FOV22 cm70 cm
    Detector ring diameter26 cm84.2 cm
    Time coincidence window4 ns4.1 ns
    System time resolution1 ns540 ps
    Energy window430–650 keV435–650 keV
    Axial resolution
     At 1 cmUp to 2 mm4.4 mm
     At 10 cmUp to 2 mm5.7 mm
    Transverse resolution
     At 1 cmUp to 2.1 mm4.4 mm
     At 10 cmUp to 3.1 mm4.9 mm
  • TABLE 2.

    Within-Participant, Across-Region Comparison of CerePET and Biograph mCT

    AtlasData typerRegression slope
    SUVKiCMRgluSUVKiCMRglu
    DKMean ± SD0.83 ± 0.070.85 ± 0.080.85 ± 0.080.84 ± 0.170.83 ± 0.170.85 ± 0.18
    COV8.74%9.15%9.15%20.70%20.62%21.62%
    SubcorticalMean ± SD0.97 ± 0.020.97 ± 0.030.97 ± 0.030.79 ± 0.140.83 ± 0.110.86 ± 0.11
    COV2.39%3.04%3.04%17.27%13.02%12.32%

    • DK = Desikan–Killiany; COV = coefficient of variation.

  • TABLE 3.

    Within-Region, Across-Participant Comparison of CerePET and Biograph mCT

    AtlasData typerRegression slope
    SUVKiCMRgluSUVKiCMRglu
    DKMean ± SD0.55 ± 0.070.58 ± 0.070.66 ± 0.080.54 ± 0.070.50 ± 0.100.55 ± 0.09
    COV12.62%11.45%11.54%13.31%21.18%16.29%
    SubcorticalMean ± SD0.55 ± 0.080.71 ± 0.070.74 ± 0.070.52 ± 0.090.68 ± 0.130.75 ± 0.11
    COV14.87%9.22%8.77%16.74%19.33%14.39%

    • DK = Desikan–Killiany; COV = coefficient of variation.

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