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Research ArticleClinical Investigation

Fibroblast Activation Protein α–Directed Imaging and Therapy of Solitary Fibrous Tumor

Rainer Hamacher, Kim M. Pabst, Phyllis F. Cheung, Christoph E. Heilig, Jennifer Hüllein, Sven-Thorsten Liffers, Sabrina Borchert, Pedro Fragoso Costa, Benedikt M. Schaarschmidt, Lukas Kessler, Monika A. Miera, Margret Droste, Merve Akbulut, Johanna Falkenhorst, Fadi Zarrad, Karina Kostbade, Ilektra A. Mavroeidi, Hanno Glimm, Lale Umutlu, Martin Schuler, Daniel Hübschmann, Sebastian Bauer, Stefan Fröhling, Ken Herrmann, Jens T. Siveke, Hans-Ulrich Schildhaus and Wolfgang P. Fendler
Journal of Nuclear Medicine February 2024, 65 (2) 252-257; DOI: https://doi.org/10.2967/jnumed.123.266411
Rainer Hamacher
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Kim M. Pabst
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Phyllis F. Cheung
4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
5Division of Solid Tumor Translational Oncology, German Cancer Consortium (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany;
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Christoph E. Heilig
6Department of Translational Medical Oncology, National Center for Tumor Diseases, Heidelberg and German Cancer Research Center, Heidelberg, Germany;
7German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany;
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Jennifer Hüllein
8Computational Oncology, Molecular Precision Oncology Program, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany;
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Sven-Thorsten Liffers
4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
5Division of Solid Tumor Translational Oncology, German Cancer Consortium (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany;
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Sabrina Borchert
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
9Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Pedro Fragoso Costa
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Benedikt M. Schaarschmidt
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
10Department of Diagnostic and Interventional Radiology and Neuroradiology, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Lukas Kessler
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Monika A. Miera
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Margret Droste
4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
5Division of Solid Tumor Translational Oncology, German Cancer Consortium (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany;
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Merve Akbulut
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Johanna Falkenhorst
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Fadi Zarrad
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Karina Kostbade
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Ilektra A. Mavroeidi
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Hanno Glimm
11Department for Translational Medical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany;
12German Cancer Research Center, Heidelberg, Germany;
13Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;
14Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany;
15Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;
16German Cancer Consortium, Dresden, Germany; and
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Lale Umutlu
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
10Department of Diagnostic and Interventional Radiology and Neuroradiology, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Martin Schuler
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Daniel Hübschmann
7German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany;
8Computational Oncology, Molecular Precision Oncology Program, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany;
17Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Heidelberg, Germany
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Sebastian Bauer
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
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Stefan Fröhling
6Department of Translational Medical Oncology, National Center for Tumor Diseases, Heidelberg and German Cancer Research Center, Heidelberg, Germany;
7German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany;
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Ken Herrmann
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Jens T. Siveke
1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
5Division of Solid Tumor Translational Oncology, German Cancer Consortium (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany;
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Hans-Ulrich Schildhaus
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
9Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Wolfgang P. Fendler
2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
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Article Information

vol. 65 no. 2 252-257
DOI 
https://doi.org/10.2967/jnumed.123.266411
PubMed 
38176718

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication July 24, 2023
  • Revision received November 7, 2023
  • Published online February 1, 2024.

Article Versions

  • previous version (January 4, 2024 - 06:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Rainer Hamacher1,2,
  2. Kim M. Pabst2,3,
  3. Phyllis F. Cheung4,5,
  4. Christoph E. Heilig6,7,
  5. Jennifer Hüllein8,
  6. Sven-Thorsten Liffers4,5,
  7. Sabrina Borchert2,9,
  8. Pedro Fragoso Costa2,3,
  9. Benedikt M. Schaarschmidt2,10,
  10. Lukas Kessler2,3,
  11. Monika A. Miera1,4,
  12. Margret Droste4,5,
  13. Merve Akbulut1,
  14. Johanna Falkenhorst1,2,
  15. Fadi Zarrad2,3,
  16. Karina Kostbade1,2,
  17. Ilektra A. Mavroeidi1,2,
  18. Hanno Glimm11,12,13,14,15,16,
  19. Lale Umutlu2,10,
  20. Martin Schuler1,2,
  21. Daniel Hübschmann7,8,17,
  22. Sebastian Bauer1,2,
  23. Stefan Fröhling6,7,
  24. Ken Herrmann2,3,
  25. Jens T. Siveke1,2,4,5,
  26. Hans-Ulrich Schildhaus*,2,9 and
  27. Wolfgang P. Fendler*,2,3
  1. 1Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;
  2. 2German Cancer Consortium, Partner site University Hospital Essen, Essen, Germany;
  3. 3Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;
  4. 4Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;
  5. 5Division of Solid Tumor Translational Oncology, German Cancer Consortium (Partner Site Essen) and German Cancer Research Center, Heidelberg, Germany;
  6. 6Department of Translational Medical Oncology, National Center for Tumor Diseases, Heidelberg and German Cancer Research Center, Heidelberg, Germany;
  7. 7German Cancer Consortium, Core Center Heidelberg, Heidelberg, Germany;
  8. 8Computational Oncology, Molecular Precision Oncology Program, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany;
  9. 9Institute of Pathology, West German Cancer Center, University Hospital Essen, Essen, Germany;
  10. 10Department of Diagnostic and Interventional Radiology and Neuroradiology, West German Cancer Center, University Hospital Essen, Essen, Germany;
  11. 11Department for Translational Medical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany;
  12. 12German Cancer Research Center, Heidelberg, Germany;
  13. 13Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;
  14. 14Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany;
  15. 15Translational Medical Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany;
  16. 16German Cancer Consortium, Dresden, Germany; and
  17. 17Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Heidelberg, Germany
  1. For correspondence or reprints, contact Rainer Hamacher (rainer.hamacher{at}uk-essen.de).
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Fibroblast Activation Protein α–Directed Imaging and Therapy of Solitary Fibrous Tumor
Rainer Hamacher, Kim M. Pabst, Phyllis F. Cheung, Christoph E. Heilig, Jennifer Hüllein, Sven-Thorsten Liffers, Sabrina Borchert, Pedro Fragoso Costa, Benedikt M. Schaarschmidt, Lukas Kessler, Monika A. Miera, Margret Droste, Merve Akbulut, Johanna Falkenhorst, Fadi Zarrad, Karina Kostbade, Ilektra A. Mavroeidi, Hanno Glimm, Lale Umutlu, Martin Schuler, Daniel Hübschmann, Sebastian Bauer, Stefan Fröhling, Ken Herrmann, Jens T. Siveke, Hans-Ulrich Schildhaus, Wolfgang P. Fendler
Journal of Nuclear Medicine Feb 2024, 65 (2) 252-257; DOI: 10.2967/jnumed.123.266411

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Fibroblast Activation Protein α–Directed Imaging and Therapy of Solitary Fibrous Tumor
Rainer Hamacher, Kim M. Pabst, Phyllis F. Cheung, Christoph E. Heilig, Jennifer Hüllein, Sven-Thorsten Liffers, Sabrina Borchert, Pedro Fragoso Costa, Benedikt M. Schaarschmidt, Lukas Kessler, Monika A. Miera, Margret Droste, Merve Akbulut, Johanna Falkenhorst, Fadi Zarrad, Karina Kostbade, Ilektra A. Mavroeidi, Hanno Glimm, Lale Umutlu, Martin Schuler, Daniel Hübschmann, Sebastian Bauer, Stefan Fröhling, Ken Herrmann, Jens T. Siveke, Hans-Ulrich Schildhaus, Wolfgang P. Fendler
Journal of Nuclear Medicine Feb 2024, 65 (2) 252-257; DOI: 10.2967/jnumed.123.266411
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  • Comparison of [68Ga]Ga-Fibroblast Activation Protein Inhibitor-04 and [18F]FDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy
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  • Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors
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