FAPI: Still more question to be answered-A review based analysis

Introduction: Over ninety percent of epithelial malignancies have elevated levels of fibroblast activation protein (FAP), a type II transmembrane serine protease that is closely associated with tumour invasion, metastasis, and prognosis. Using FAP as a target, different FAP inhibitors (FAPIs) have been developed; the majority of these FAPIs have nanomolar levels of FAP affinity and high selectivity, and they are used for positron emission tomography (PET) imaging of diverse cancers. FAPIs are projected to be the new molecule of the century with greater imaging effects than 18F-FDG in a number of diseases, such as gastrointestinal tumours, liver tumours, breast tumours, and nasopharyngeal carcinoma, based on current research. FAPIs are a complementing molecular imaging method to 18F-FDG. Current paper present the review of currebntly published litreature in terms of FAPI and its clinical role in oncology.

Methods: The author did a thorough review of all the articles and clinical trials that came out in the last three years, using databases like PubMed, Medline, and EBSCO. All of the literature that was looked at was summed up and evaluated so that the role of FDG and other receptor-based imaging techniques (PSMA and DOTA) could be compared with the role of FAPI only imaging. The real question was whether FAPI imaging alone is the answer to everything or whether we still need other approved imaging before FAPI imaging.

Results: The reviewed literature demonstrated a trend towards discordant imaging rather than FAPI alone, since the biological changes and an increase in FAPI have not been able to fix the obvious problems. In order to properly plan treatment for patients, conventional imaging, which may include FDG, PSMA, or DOTA, is still essential. This is because each of these procedures is a uniquely customised diagnostic test that is necessary..

Conclusions: The reviewed literature suggests that further research has to be conducted before FAPI-based PET imaging may be used as a primary scanning approach since there are still many questions that have not been resolved.