Abstract
P803
Introduction: The overall goal of this project is to develop economical, patient friendly technology to enable personalization of Lu-177 DOTATATE therapy based upon dose to a patient's organs at risk and tumors. To achieve this goal, we have been developing personalized remote radiation tracking (PRRT) technology that enables monitoring of activity from a patient's organs at risk using a device that the patient can use and operate from their home.
Methods: The personalized remote radiation tracking portable organ dosimetry device (PRRT PODD) consists of a rigid base plate, a patient specific registration/alignment pad, and two wings that encircle the patient’s mid-section when closed. The patient will lie down in their PRRT PODD template device during their pre-therapy DOTATATE PET/CT scan. This registers the PODD with their internal organs and tumors. Using this information, specialized software determines where to place up to 16 small radiation detectors on the framework of the PODD to optimally obtain quantitative radiation activity measurements from the patient’s organs at risk, background tissues and tumors. The patient specific registration pad enables accurate positioning of the patient’s body in the PODD during each measurement session. Compact, custom electronics have been built for signal processing, data acquisition and data transfer to a laptop computer. The electronics fit within a 3 ¼" by 2 ¼" by 1 ¾" volume and are powered by a small rechargeable battery, such as found in cell phones. Cost of the electronics is modest due to the availability of low-cost IoT consumer electronic boards. The detector electronics are housed within the base unit of the PRRT PODD. In our current protocol, the patient receives a quantitative SPECT/CT scan at 24 hours after dose administration. After this scan, the personalized PODD will be sent home with the patient for daily 2-minute data acquisitions for up to 14 days. The data after daily acquisition will be securely transmitted electronically to a remote workstation for data storage and quality control processing. After collection of the complete set of PODD data, software tools will be used to generate datasets that can be imported into OLINDA or other dose-measurement software.
Results: All components of the PRRT PODD have been designed, fabricated, and tested. The electronics support up to 16 detectors and exhibit virtually no deadtime at the counting rates expected from patients receiving 177Lu-DOTATATE treatments. All components used for the PRRT PODD template assembly have been verified to be CT compatible. The weight of the whole assembly is less than 15 lbs and easily transportable. Initial testing has begun using an anthropomorphic phantom.
Conclusions: The first full prototype of the PRRT PODD has been built. All individual components have been tested and are meeting design goals. The key features of the PRRT PODD are portability; reproducible patient positioning and data collection; compact detectors and electronics; wireless communication; and remote quality control testing. All components of the PRRT PODD are reusable except for the patient registration pad and fabric coverings used on the registration pad and wings of the PODD.
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