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Research ArticleFEATURED ARTICLE OF THE MONTH

Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study

Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L. Ross, Jochen Tillmanns, James T. Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs and Frank M. Bengel
Journal of Nuclear Medicine August 2023, 64 (8) 1279-1286; DOI: https://doi.org/10.2967/jnumed.122.265147
Johanna Diekmann
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Jonas Neuser
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Manuel Röhrich
3Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Thorsten Derlin
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Carolin Zwadlo
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Tobias Koenig
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Desiree Weiberg
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Felix Jäckle
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Tibor Kempf
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Tobias L. Ross
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Jochen Tillmanns
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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James T. Thackeray
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Julian Widder
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Uwe Haberkorn
3Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
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Johann Bauersachs
2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
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Frank M. Bengel
1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
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Article Information

vol. 64 no. 8 1279-1286
DOI 
https://doi.org/10.2967/jnumed.122.265147
PubMed 
37290793

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication November 7, 2022
  • Revision received April 10, 2023
  • Published online August 1, 2023.

Article Versions

  • previous version (June 8, 2023 - 07:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Johanna Diekmann*,1,
  2. Jonas Neuser*,2,
  3. Manuel Röhrich3,
  4. Thorsten Derlin1,
  5. Carolin Zwadlo2,
  6. Tobias Koenig2,
  7. Desiree Weiberg1,
  8. Felix Jäckle2,
  9. Tibor Kempf2,
  10. Tobias L. Ross1,
  11. Jochen Tillmanns2,
  12. James T. Thackeray1,
  13. Julian Widder2,
  14. Uwe Haberkorn3,
  15. Johann Bauersachs*,2 and
  16. Frank M. Bengel*,1
  1. 1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany;
  2. 2Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany; and
  3. 3Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany
  1. For correspondence or reprints, contact Johanna Diekmann (diekmann.johanna{at}mh-hannover.de).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 64 (8)
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August 1, 2023
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Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study
Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L. Ross, Jochen Tillmanns, James T. Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs, Frank M. Bengel
Journal of Nuclear Medicine Aug 2023, 64 (8) 1279-1286; DOI: 10.2967/jnumed.122.265147

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Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study
Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L. Ross, Jochen Tillmanns, James T. Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs, Frank M. Bengel
Journal of Nuclear Medicine Aug 2023, 64 (8) 1279-1286; DOI: 10.2967/jnumed.122.265147
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  • Nuclear Cardiology Surrogate Biomarkers in Clinical Trials
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Keywords

  • aortic stenosis
  • myocardial fibrosis
  • molecular imaging
  • fibroblast activation protein
  • PET
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