Article Figures & Data
Figures
- FIGURE 1.
Patient example of remaining active thyroid tissue seen on 99mTc-pertechnetate scintigraphy (left) and no uptake 3 mo after ATR (right).
- FIGURE 2.
Significant decrease in TRAb level, thyroid volume, and uptake on 99mTc-pertechnetate scintigraphy at 3-mo follow-up compared with baseline, indicating successful ATR. *P ≤ 0.05. ****P ≤ 0.0001. TcTu = 99mTc uptake.
- FIGURE 3.
Significant decrease in disease activity as assessed with soft-tissue score and CAS at 3 and 12 mo after ATR, compared with baseline. NOSPECS also showed significant decrease (P = 0.013) at both time points. Proptosis was mostly stable, with no significant improvement. *P ≤ 0.05. **P ≤ 0.01. ***P ≤ 0.001. ****P ≤ 0.0001; ns = not statistically significant.
Tables
Characteristic Data Subjects 100% (30) Age (y) 52.1 ± 9.9 Female 90% (27) Duration of thyroid disease (y) 2.7 (1–16) Duration from primary thyroid treatment to ATR (mo) 17.5 (1–256) 99mTc uptake (%) 0.2 (0.01–1.7) Lobus pyramidalis present at baseline 50% (15) ATR Oral steroids during ATR 83% (25) Intravenous steroids during ATR 17% (5) GO status at baseline Mild 13% (4) Moderate-to-severe 83% (25) Very severe 3% (1) Previous steroid therapy 83% (25) Subsequent steroid therapy 20% (6) Qualitative data are percentage and number; continuous data are mean ± SD or median and range.
Parameter Baseline 3 mo after TTA 12 mo after TTA LT4 dose (μg) 81.5 ± 42.5 101 ± 26.9 108 ± 25.8 TRAb (IU/L) 18.4 (1.4–>40) 13.4 (0.58–>40) Thyroid volume (cm3) 0.95 (0–5.5) 0.05 (0–2) Data are mean ± SD or median and range. N = 30 subjects.
Parameter Data Target volume (cm3) 0.95 (0–5.5) Activity (MBq of 131I) 411 (100–1,036) Thyroid remnant dose (Gy) 488 (63–2,153) 24-h radioiodine uptake (%) 13.4 ± 7 Effective half-life (d) 2.8 ± 1.5 Data are mean ± SD or median and range. N = 30 subjects.
Parameter Baseline 3 mo after TTA 12 mo after TTA CAS 3.4 ± 1.8 1.9 ± 1.6 1.3 ± 1.2 NOSPECS 5.9 ± 1.9 5.1 ± 2.6 4.9 ± 2 Soft-tissue score 4.7 ± 2.6 3.4 ± 2.9 2.1 ± 2.1 Proptosis (mm) 18.4 (13–24.5) 18.1 (13–24) 17.9 (14–22) Motility (°) 296.8 (157–350) 302.2 (215–350) 298.6 (180–350) Data are mean ± SD or median and range. N = 30 subjects.
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