Article Figures & Data
Figures
- FIGURE 1.
Flowchart of analyzed patients. CCA = cholangiocarcinoma; HCC = hepatocellular carcinoma.
- FIGURE 2.
A 64-y-old man with stage 4 iCCA with lymph node metastases. (A and B) Initial MRI shows hypovascularized tumor in right liver lobe (A, arrow), with faint contrast agent uptake in preinterventional angiography with subsequent 99mTc-macroaggregated albumin injection (B, arrow). Radioembolization of right hepatic artery with 4.64 GBq was performed 27 d after 99mTc-macroaggregated albumin injection. (C) Postinterventional MRI 126 d after radioembolization showed partial tumor response (arrow). Patient died after 176 d.
- FIGURE 3.
Kaplan–Meier survival curves for different tumor characteristics in analyzed cohort: tumor type (A), hepatic tumor burden (B), and tumor vascularization pattern (C).
- FIGURE 4.
Kaplan–Meier survival curves for different baseline characteristics in analyzed cohort: extrahepatic metastases (A), liver cirrhosis (B), and ascites (C).
- FIGURE 5.
Kaplan–Meier survival curves for different treatment lines in analyzed cohort.
- FIGURE 6.
Forest plot for multivariable Cox regression analysis. dof = degrees of freedom.
Tables
Characteristic % n Initial UICC tumor stage I 1.4 2 II 21 29 IIIa 14.5 20 IIIb 38.5 53 IV 20.3 28 Unknown 4.3 6 Tumor type Mass-forming 58.7 81 Diffuse intrahepatic 39.9 55 Unknown 1.4 2 Tumor vascularization Hypervascularized 34.8 48 Hypovascularized 36.2 50 Mixed appearance 22.5 31 Unknown 6.5 9 Hepatic tumor burden <25% 52.2 72 25%–50% 25.4 35 >50% 15.2 21 Unknown 7.2 10 Distant metastases at time of radioembolization Yes 43.5 60 Lymph nodes 10.1 14 Peritoneum 7.2 10 Pancreas 0.7 1 Lung 10.9 15 Bone 5.1 7 Brain 2.2 3 No 56.5 78 Liver cirrhosis at time of radioembolization Yes 15.9 22 No 83.4 115 Unknown 0.7 1 Ascites at time of radioembolization Yes 23.9 33 No 76.1 105 Treatment % n Prior therapy Yes 84.6 103 Hepatic surgery 31.9 44 Extrahepatic surgery 3.6 5 Radiation 2.9 4 Radioembolization 7.2 10 TACE/TAE/HAI 5.1 7 Local ablation (MWA/RFA) 5.8 8 Chemotherapy 62.3 86 Tyrosine kinase inhibitor therapy 2.2 3 No 25.4 35 First-line radioembolization 25.4 35 Second-line radioembolization 38.4 53 Salvage radioembolization 36.2 50 HAI = hepatic artery infusion; MWA = microwave ablation; RFA = radiofrequency ablation.
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