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Meeting ReportGeneral Clinical Specialties

18F-FDG PET/CT Imaging of Infection and Inflammation

Sara Harsini, Thomas Werner, Mona-Elisabeth Revheim, Abass Alavi and Babak Saboury
Journal of Nuclear Medicine June 2022, 63 (supplement 2) 2669;
Sara Harsini
1BC Cancer
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Thomas Werner
2Hospital of the University of Pennsylvania
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Mona-Elisabeth Revheim
3Oslo University Hospital and University of Oslo
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Abass Alavi
4University of Pennsylvania
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Babak Saboury
5National Institutes of Health (NIH) - Clinical Center
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Abstract

2669

Introduction: To review and characterize the role of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in sterile and septic inflammatory processes.

Methods: Since the initial clinical utilization of the glucose analogue, 18F-FDG, clinicians have understood the potentiality of this radiopharmaceutical for the evaluation of an important and diverse group of pathological conditions, characterized by infection and aseptic inflammation. Given the high energy consumption of white blood cells activated by either a pathogen or as part of a systemic inflammatory disease and therefore avidly taking up 18F-FDG, it is not surprising that a rapidly expanding body of evidence now supports the clinical utility of 18F-FDG PET/CT in suspected infection and inflammation. 18F-FDG PET/CT can identify the source of infection or inflammation in a timely manner prior to the appearance of morphological changes on conventional anatomical imaging modalities, map the disease extent, characterize sites for tissue sampling, and evaluate therapy response. This yet evolving hybrid imaging technique offers distinct advantages over traditional radionuclide imaging techniques, such as higher spatial resolution, shorter duration of imaging, integration of functional and anatomical data, and the non-invasive nature of the acquisition.

Results: We will discuss the utility of 18F-FDG in inflammatory and infectious diseases such as osteomyelitis, cardiac implantable electronic device infection, infective endocarditis, prosthetic valve endocarditis, vascular graft infection, prosthetic joint infection, fever of unknown origin (FUO), COVID-19 infection, tuberculosis, sarcoidosis, human immunodeficiency virus (HIV)-related disease and autoimmune conditions such as vasculitis, inflammatory bowel diseases, IgG4-related diseases and rheumatoid arthritis.

Conclusions: This educational exhibit will highlight the utility and limitations of 18F-FDG PET/CT for the diagnosis and assessment of treatment in infections and inflammatory conditions.

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Journal of Nuclear Medicine
Vol. 63, Issue supplement 2
June 1, 2022
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18F-FDG PET/CT Imaging of Infection and Inflammation
Sara Harsini, Thomas Werner, Mona-Elisabeth Revheim, Abass Alavi, Babak Saboury
Journal of Nuclear Medicine Jun 2022, 63 (supplement 2) 2669;

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18F-FDG PET/CT Imaging of Infection and Inflammation
Sara Harsini, Thomas Werner, Mona-Elisabeth Revheim, Abass Alavi, Babak Saboury
Journal of Nuclear Medicine Jun 2022, 63 (supplement 2) 2669;
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