Article Figures & Data
Figures
- FIGURE 1.
Deep-learning–enabled segmentation of anatomic context in low-dose CT component of PET/CT. Individual color represents respective segmented organ. aPROMISE technology enables automated segmentation of reference organs and anatomic delineation of disease in prostate tumor, regional lymph node, and distant metastases.
- FIGURE 2.
Example of patients who were negative in aPROMISE-assisted reads of 18F-DCFPyL scans (A and C, axial images) compared with Na18F (B and D, axial images) and were downstaged from N0M1 to N0M0.
- FIGURE 3.
Quantitative reproducibility of miPSMA index in patients who were categorized the same in 2 independent aPROMISE-assisted reads: miN0M0 (A), miN1M0 (B), and miN0M1(C). In A, 1 patient was excluded because of a manual segmentation error that incorporated bladder. Cor = correlation.
- FIGURE 4.
miPSMA index values in prostate, stratified by PSA (A and B) and separately by Gleason grade (C).
Tables
Characteristic Data Age (y) Average 70 Median 69 Minimum 55 Maximum 86 Race (n) White 54 (49%) African American 44 (41%) Hispanic 7 (7%) Asian Pacific Islander 3 (2%) Native American 1 (1%) Clinical T stage (n) cT1/2 62 (57%) cT3 47 (43%) Gleason score (n) 3 + 3 13 (7%) 3 + 4 28 (23%) 4 + 3 24 (18%) ≥4 + 4 49 (36%) PSA at diagnosis (ng/mL) Average 20.4 ng/mL Median 13.55 ng/mL Minimum 3.03 ng/mL Maximum 167.92 ng/mL Percentage positive core (n) <25% 18 (17%) 25%–50% 28 (26%) 51%–75% 14 (13%) >75% 28 (26%) Unknown 11 (10%) - TABLE 2.
aPROMISE-PSMA Staging Reads vs. Local and Distant Metastatic Staging by Conventional Imaging
Conventional imaging Read no. Parameter N0M0 (n = 87) N1M0 (n = 8) N0M1a/b (n = 14) N1M1a/b (n = 0) 1 miN0M0 (n = 71) 67 0 4 0 miN1M0 (n = 19) 13 6 0 0 miN0 M1a/b (n = 15) 6 0 9 0 miN1M1a/b (n = 4) 1 2 1 0 2 miN0M0 (n = 72) 68 0 4 0 miN1M0 (n = 18) 12 6 0 0 miN0M1a/b (n = 15) 6 0 9 0 miN1M1a/b (n = 4) 1 2 1 0 n = 109.
- TABLE 3.
Local and Distant Metastatic Staging by aPROMISE-PSMA Read 1 Against aPROMISE-PSMA Read 2
Read 1 Read 2 miN0M0 (n = 71) miN1M0 (n = 19) miN0M1a/b (n = 15) miN1M1a/b (n = 4) miN0M0 (n = 72) 67 2 3 0 miN1M0 (n = 18) 1 17 0 0 miN0M1a/b (n = 15) 3 0 12 0 miN1M1a/b (n = 4) 0 0 0 4 n = 109.
