[11C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain

Xuefeng Yan; Sanjay Telu; Rachel Dick; Jeih-San Liow; Paolo Zanotti-Fregonara; Cheryl Morse; Lester Manly; Robert Gladding; Stal Shrestha; Walter Lerchner; Yuji Nagai; Takafumi Minamimoto; Sami Zoghbi; Robert Innis; Victor Pike; Barry Richmond; Mark Eldridge

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[¹¹C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain

Xuefeng Yan, Sanjay Telu, Rachel Dick, Jeih-San Liow, Paolo Zanotti-Fregonara, Cheryl Morse, Lester Manly, Robert Gladding, Stal Shrestha, Walter Lerchner, Yuji Nagai, Takafumi Minamimoto, Sami Zoghbi, Robert Innis, Victor Pike, Barry Richmond and Mark Eldridge

Journal of Nuclear Medicine May 2021, 62 (supplement 1) 120;

Xuefeng Yan

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Sanjay Telu

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Rachel Dick

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Jeih-San Liow

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Paolo Zanotti-Fregonara

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Cheryl Morse

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Lester Manly

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Robert Gladding

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Stal Shrestha

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Walter Lerchner

2Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Yuji Nagai

3Department of Functional Brain Imaging, National institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan

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Takafumi Minamimoto

3Department of Functional Brain Imaging, National institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan

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Sami Zoghbi

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Robert Innis

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Victor Pike

1Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Barry Richmond

2Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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Mark Eldridge

2Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health Bethesda MD United States

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[¹¹C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain

Journal of Nuclear Medicine May 2021, 62 (supplement 1) 120;

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[¹¹C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain

Journal of Nuclear Medicine May 2021, 62 (supplement 1) 120;

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[¹¹C]Deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain

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