Development and Evaluation of Interleukin-2–Derived Radiotracers for PET Imaging of T Cells in Mice

Elly L. van der Veen; Frans V. Suurs; Frederik Cleeren; Guy Bormans; Philip H. Elsinga; Geke A.P. Hospers; Marjolijn N. Lub-de Hooge; Elisabeth G.E. de Vries; Erik F.J. de Vries; Inês F. Antunes

doi:10.2967/jnumed.119.238782

Research ArticleMolecular Imaging

Development and Evaluation of Interleukin-2–Derived Radiotracers for PET Imaging of T Cells in Mice

Elly L. van der Veen, Frans V. Suurs, Frederik Cleeren, Guy Bormans, Philip H. Elsinga, Geke A.P. Hospers, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Erik F.J. de Vries and Inês F. Antunes

Journal of Nuclear Medicine September 2020, 61 (9) 1355-1360; DOI: https://doi.org/10.2967/jnumed.119.238782

Elly L. van der Veen

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Frans V. Suurs

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Frederik Cleeren

2Laboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium

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Guy Bormans

2Laboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven, Leuven, Belgium

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Philip H. Elsinga

3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

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Geke A.P. Hospers

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Marjolijn N. Lub-de Hooge

3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

4Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Elisabeth G.E. de Vries

1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Erik F.J. de Vries

3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

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Inês F. Antunes

3Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

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Development and Evaluation of Interleukin-2–Derived Radiotracers for PET Imaging of T Cells in Mice

Elly L. van der Veen, Frans V. Suurs, Frederik Cleeren, Guy Bormans, Philip H. Elsinga, Geke A.P. Hospers, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Erik F.J. de Vries, Inês F. Antunes

Journal of Nuclear Medicine Sep 2020, 61 (9) 1355-1360; DOI: 10.2967/jnumed.119.238782

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Development and Evaluation of Interleukin-2–Derived Radiotracers for PET Imaging of T Cells in Mice

Elly L. van der Veen, Frans V. Suurs, Frederik Cleeren, Guy Bormans, Philip H. Elsinga, Geke A.P. Hospers, Marjolijn N. Lub-de Hooge, Elisabeth G.E. de Vries, Erik F.J. de Vries, Inês F. Antunes

Journal of Nuclear Medicine Sep 2020, 61 (9) 1355-1360; DOI: 10.2967/jnumed.119.238782

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Keywords

PET imaging
T cells
immunotherapy
interleukin-2
radiopharmaceuticals

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