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Tables
Parameter Total (n = 1,193) AD (n = 960) FTD (n = 36) MCI (n = 144) DLB (n = 5) CBS (n = 4) VaD (n = 29) UN-D (n = 15) Median age (y) 65.0 (range, 19–92) 65.1 (range, 32–92) 60.4 (range, 38–79) 61.5 (range, 30–90) 71.0 (range, 61–77) 63.5 (range, 51–77) 70.0 (range, 53–81) 56.5 (range, 19–74) Age group (n) <40 y 18 13 1 1 0 0 0 3 40–49 y 64 39 6 16 0 0 0 3 50–59 y 300 241 9 43 0 1 4 2 60–69 y 395 316 15 46 1 2 10 5 70–79 y 322 265 5 31 4 1 14 2 ≥80 y 94 86 0 7 0 0 1 0 Men (n) 661 (55.4%) 525 (54.7%) 15 (41.7%) 91 (63.2%) 3 (60.0%) 2 (50.0%) 15 (51.7%) 10 (66.7%) Education level (y)* 11.2 ± 3.7 10.9 ± 3.5 10.3 ± 3.1 13 ± 3.3 14.7 ± 2.3 8.8 ± 6.2 10.8 ± 4.2 13.7 ± 4.0 MMSE score* 19.2 ± 6.7 17.4 ± 6.3 19.0 ± 7.5 24.7 ± 4.0 20.3 ± 6.7 18.0 ± 4.0 22.8 ± 6.9 26.7 ± 3.2 MoCA score* 13.8 ± 6.9 12.0 ± 6.0 12.3 ± 7.7 19.3 ± 5.6 15.0 ± 11.7 7.3 ± 3.1 17.5 ± 8.5 21.7 ± 5.1 ADL score* 28.0 ± 9.7 29.6 ± 8.9 28.3 ± 11.1 21.3 ± 1.8 28.0 ± 7.5 40.0 ± 2.0 27.9 ± 13.8 25.3 ± 6.1 *Data are mean ± SD.
UN-D = unclassifiable dementia; ADL = Activities-of-Daily-Living Scale.
- TABLE 2
Observed Probabilities of Amyloid Positivity on PET Across Diagnostic and Age Groups
Parameter Total (n = 1,193) AD (n = 960) FTD (n = 36) MCI (n = 144) DLB (n = 5) CBS (n = 4) VaD (n = 29) UN-D (n = 15) Total 860 (72.1) 833 (86.8) 2 (5.6) 14 (9.7) 3 (60.0) 2 (50.0) 6 (20.7) 0 Age group <40 y 12/18 (66.7) 12/13 (92.3) 0/1 0/1 0 0 0 0/5 40–49 y 32/64 (50.0) 32/39 (82.1) 0/6 0/16 0 0 0 0/3 50–59 y 221/300 (73.7) 213/241 (88.4) 1/9 (11.1) 6/43 (14.0) 0 0/1 1/4 (25.0) 0/2 60–69 y 286/395 (72.4) 275/316 (87.0) 1/15 (6.7) 6/46 (13.0) 1/1 (100) 1/2 (50.0) 2/10 (20.0) 0/5 70–79 y 239/322 (74.2) 231/265 (87.2) 0/5 2/31 (6.5) 2/4 (50.0) 1/1 (100) 3/14 (21.4) 0/2 ≥80 y 70/94 (74.5) 70/86 (81.4) 0 0/7 0 0 0/1 0 Sex Men 454/661 (68.7) 441/525 (84.0) 0/15 8/91 (8.8) 2/3 (66.7) 1/2 (50.0) 2/15 (13.3) 0/10 Women 406/532 (76.3) 392/435 (90.1) 2/21 (9.5) 6/53 (11.3) 1/2 (50.0) 1/2 (50.0) 4/14 (28.6) 0/5 UN-D = unclassifiable dementia.
Data are n followed by percentage in parentheses.
- TABLE 3
Prevalence of Amyloid Positivity on PET Scans Across Diagnostic, Sex, and Age Groups
Parameter Amyloid-positive P Diagnosis <0.001 AD 833 (86.7) FTD 2 (5.6) MCI 14 (9.7) DLB + CBS 5 (55.6) VaD 6 (20.7) Total group Age group 0.004 <40 y 12 (66.7) 40–49 y 32 (50.0) 50–59 y 221 (73.7) 60–69 y 286 (72.4) 70–79 y 239 (74.2) ≥80 y 70 (74.5) Sex 0.002 Men 454 (68.7) Women 406 (76.3) AD group Age group 0.569 <40 y 12 (92.3) 40–49 y 32 (82.1) 50–59 y 213 (88.4) 60–69 y 275 (87.0) 70–79 y 231 (87.2) ≥80 y 70 (81.4) Sex 0.004 Men 441 (83.4) Women 392 (90.1) Data are n followed by percentage in parentheses.
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