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Journal of Nuclear Medicine

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Research ArticleTheranostics

Design and Development of 99mTc-Labeled FAPI Tracers for SPECT Imaging and 188Re Therapy

Thomas Lindner, Annette Altmann, Susanne Krämer, Christian Kleist, Anastasia Loktev, Clemens Kratochwil, Frederik Giesel, Walter Mier, Frederik Marme, Jürgen Debus and Uwe Haberkorn
Journal of Nuclear Medicine October 2020, 61 (10) 1507-1513; DOI: https://doi.org/10.2967/jnumed.119.239731
Thomas Lindner
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Annette Altmann
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Susanne Krämer
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Christian Kleist
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Anastasia Loktev
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Clemens Kratochwil
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Frederik Giesel
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Walter Mier
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
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Frederik Marme
3Translational Gynecologic Oncology, University Hospital Mannheim, Mannheim, Germany; and
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Jürgen Debus
4Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany
5Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Uwe Haberkorn
1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg Germany
2Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
6Translational Lung Research Center Heidelberg, German Center for Lung Research (DZL), Heidelberg, Germany
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Journal of Nuclear Medicine: 61 (10)
Journal of Nuclear Medicine
Vol. 61, Issue 10
October 1, 2020
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Design and Development of 99mTc-Labeled FAPI Tracers for SPECT Imaging and 188Re Therapy
Thomas Lindner, Annette Altmann, Susanne Krämer, Christian Kleist, Anastasia Loktev, Clemens Kratochwil, Frederik Giesel, Walter Mier, Frederik Marme, Jürgen Debus, Uwe Haberkorn
Journal of Nuclear Medicine Oct 2020, 61 (10) 1507-1513; DOI: 10.2967/jnumed.119.239731

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Design and Development of 99mTc-Labeled FAPI Tracers for SPECT Imaging and 188Re Therapy
Thomas Lindner, Annette Altmann, Susanne Krämer, Christian Kleist, Anastasia Loktev, Clemens Kratochwil, Frederik Giesel, Walter Mier, Frederik Marme, Jürgen Debus, Uwe Haberkorn
Journal of Nuclear Medicine Oct 2020, 61 (10) 1507-1513; DOI: 10.2967/jnumed.119.239731
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  • Localized In Vivo Prodrug Activation Using Radionuclides
  • Diagnostic Accuracy of 68Ga-FAPI Versus 18F-FDG PET in Patients with Various Malignancies
  • Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions
  • Fibroblast-Activation Protein PET and Histopathology in a Single-Center Database of 324 Patients and 21 Tumor Entities
  • Clinical Translation of Targeted {alpha}-Therapy: An Evolution or a Revolution?
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  • Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer
  • FAPI PET/CT: Will It End the Hegemony of 18F-FDG in Oncology?
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Theranostics

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Basic

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Keywords

  • fibroblast activating protein
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  • theranostics
  • small molecule inhibitor
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