Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Meeting ReportCardiovascular

The cost-effectiveness of myocardial perfusion imaging for the detection of significant coronary artery disease in patients undergoing pre-operative liver transplantation evaluation: economic modeling and decision analysis with validation by a retrospective observational study in 215 consecutive patients.

Thomas Rosamond and Amy Feldkamp
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 1426;
Thomas Rosamond
2Kansas University Medical Center Leawood KS United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amy Feldkamp
1Kansas University Medical Center Kansas City KS United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

1426

Purpose: Screening for significant coronary artery disease (CAD) in pre-liver transplant candidates is controversial due to concerns about screening test (ST) accuracy and cost-effectiveness (CE). This economic evaluation modeling study was performed to determine the CE of the widely available CAD screening test strategies including a no imaging CAD screening test strategy (NST). dobutamine stress echo, myocardial perfusion imaging, invasive cardiac catheterization, with invasive coronary FFR as the gold standard diagnostic test. Materials and Methods: A retrospective review of 215 consecutive transplant candidates was conducted to define model inputs for decisional analysis. Perspective: a tertiary academic medical center in the USA. Other sources: extant literature review, including systematic reviews and meta-analysis, hospital accounting and clinical testing performance certification data and expert panel input using a modified Delphi exercise. Outcome measures: net monetary benefit (NMB), willingness-to-pay criteria, incremental health care cost and quality adjusted life-years (QALY’s) gained, threshold analysis, cost-effectiveness acceptability curves, one-way and probabilistic sensitivity analysis with Monte Carlo simulation. Half-cycle correction for both costs and outcome effects assuming discount rate of 3.5%. Markov node cycle length: one year with a 20-year time frame and a Dirichlet distribution structure allowing for a fully probabilistic transition matrix.

Results: MPI is the optimal strategy with a net effect of 4.56 QALYs and an incremental effect of 1.05 QALY’s gained at an incremental cost of $31,423 equivalent to $29,905 per QALY gained (ICER) when compared to the undominated NST. MPI resulted in a NMB of $30,830 assuming a WTP of $50,000 at a cost per QALY of $43,233. MPI demonstrated extended dominance over the alternative screening test stratagems included in the model. According to sensitivity analysis the results are dependent only upon the prevalence of CAD in the population under investigation but were insensitive to screening test and interventional costs.

Conclusions: When compared to a NST, MPI may be more cost-effective than other imaging modalities in the evaluation of liver transplant candidates.

Previous
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 60, Issue supplement 1
May 1, 2019
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The cost-effectiveness of myocardial perfusion imaging for the detection of significant coronary artery disease in patients undergoing pre-operative liver transplantation evaluation: economic modeling and decision analysis with validation by a retrospect…
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
The cost-effectiveness of myocardial perfusion imaging for the detection of significant coronary artery disease in patients undergoing pre-operative liver transplantation evaluation: economic modeling and decision analysis with validation by a retrospective observational study in 215 consecutive patients.
Thomas Rosamond, Amy Feldkamp
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 1426;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The cost-effectiveness of myocardial perfusion imaging for the detection of significant coronary artery disease in patients undergoing pre-operative liver transplantation evaluation: economic modeling and decision analysis with validation by a retrospective observational study in 215 consecutive patients.
Thomas Rosamond, Amy Feldkamp
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 1426;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Cardiovascular

  • Cardiac β-Adrenergic Receptor Downregulation, Evaluated by Cardiac PET, in Chronotropic Incompetence
  • Diagnostic Performance of PET Versus SPECT Myocardial Perfusion Imaging in Patients with Smaller Left Ventricles: A Substudy of the 18F-Flurpiridaz Phase III Clinical Trial
  • Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
Show more Cardiovascular

Cardiovascular Clinical Science Posters

  • Analysis of the influence of CT attenuation correction on IQ-SPECT myocardial perfusion imaging
  • Thoracic aorta atherosclerosis in multiple myeloma patients assessed by18F sodium fluoride PET/CT
  • BIUX2 X2
Show more Cardiovascular Clinical Science Posters

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire