Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro

Xi-Feng Jin; Christoph J. Auernhammer; Harun Ilhan; Simon Lindner; Svenja Nölting; Julian Maurer; Gerald Spöttl; Michael Orth

doi:10.2967/jnumed.118.224048

Research ArticleOncology

Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro

Xi-Feng Jin, Christoph J. Auernhammer, Harun Ilhan, Simon Lindner, Svenja Nölting, Julian Maurer, Gerald Spöttl and Michael Orth

Journal of Nuclear Medicine September 2019, 60 (9) 1240-1246; DOI: https://doi.org/10.2967/jnumed.118.224048

Xi-Feng Jin

1Department of Internal Medicine 4, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

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Christoph J. Auernhammer

1Department of Internal Medicine 4, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

2Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University of Munich, Munich, Germany

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Harun Ilhan

2Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University of Munich, Munich, Germany

3Department of Nuclear Medicine, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

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Simon Lindner

3Department of Nuclear Medicine, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

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Svenja Nölting

1Department of Internal Medicine 4, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

2Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University of Munich, Munich, Germany

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Julian Maurer

1Department of Internal Medicine 4, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

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Gerald Spöttl

1Department of Internal Medicine 4, University-Hospital Campus Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

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Michael Orth

4Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany

5German Cancer Consortium (DKTK), Munich, Germany; and

6German Cancer Research Center (DKFZ), Heidelberg, Germany

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Journal of Nuclear Medicine

Vol. 60, Issue 9

September 1, 2019

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Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro

Xi-Feng Jin, Christoph J. Auernhammer, Harun Ilhan, Simon Lindner, Svenja Nölting, Julian Maurer, Gerald Spöttl, Michael Orth

Journal of Nuclear Medicine Sep 2019, 60 (9) 1240-1246; DOI: 10.2967/jnumed.118.224048

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Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro

Xi-Feng Jin, Christoph J. Auernhammer, Harun Ilhan, Simon Lindner, Svenja Nölting, Julian Maurer, Gerald Spöttl, Michael Orth

Journal of Nuclear Medicine Sep 2019, 60 (9) 1240-1246; DOI: 10.2967/jnumed.118.224048

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Keywords

neuroendocrine tumor (NET)
peptide receptor radionuclide therapy (PRRT)
peptide receptor chemoradionuclide therapy (PRCRT)
5-fluorouracil (5-FU)
decitabine
tacedinaline

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Combination of 5-Fluorouracil with Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression, and Radioligand Binding in Neuroendocrine Tumor Cells In Vitro

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