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Research ArticleNeurology

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger and Matthias Brendel
Journal of Nuclear Medicine April 2019, 60 (4) 548-554; DOI: https://doi.org/10.2967/jnumed.118.217703
Carola Focke
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Tanja Blume
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
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Benedikt Zott
3Institute of Neuroscience, Technical University of Munich, Munich, Germany
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Yuan Shi
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
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Maximilian Deussing
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Finn Peters
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
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Claudio Schmidt
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Gernot Kleinberger
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
6Biomedical Center, Biochemistry, Ludwig-Maximilians-University of Munich, Munich, Germany
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Simon Lindner
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Franz-Josef Gildehaus
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Leonie Beyer
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Barbara von Ungern-Sternberg
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
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Peter Bartenstein
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
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Laurence Ozmen
7Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
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Karlheinz Baumann
7Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
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Mario M. Dorostkar
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
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Christian Haass
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
6Biomedical Center, Biochemistry, Ludwig-Maximilians-University of Munich, Munich, Germany
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Helmuth Adelsberger
3Institute of Neuroscience, Technical University of Munich, Munich, Germany
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Jochen Herms
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
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Axel Rominger
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
8Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland
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Matthias Brendel
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
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Journal of Nuclear Medicine: 60 (4)
Journal of Nuclear Medicine
Vol. 60, Issue 4
April 1, 2019
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Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Apr 2019, 60 (4) 548-554; DOI: 10.2967/jnumed.118.217703

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Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Apr 2019, 60 (4) 548-554; DOI: 10.2967/jnumed.118.217703
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