Research ArticleNeurology
Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger and Matthias Brendel
Journal of Nuclear Medicine April 2019, 60 (4) 548-554; DOI: https://doi.org/10.2967/jnumed.118.217703
Carola Focke
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Tanja Blume
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
Benedikt Zott
3Institute of Neuroscience, Technical University of Munich, Munich, Germany
Yuan Shi
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
Maximilian Deussing
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Finn Peters
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
Claudio Schmidt
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Gernot Kleinberger
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
6Biomedical Center, Biochemistry, Ludwig-Maximilians-University of Munich, Munich, Germany
Simon Lindner
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Franz-Josef Gildehaus
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Leonie Beyer
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Barbara von Ungern-Sternberg
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
Peter Bartenstein
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
Laurence Ozmen
7Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
Karlheinz Baumann
7Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland; and
Mario M. Dorostkar
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
Christian Haass
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
6Biomedical Center, Biochemistry, Ludwig-Maximilians-University of Munich, Munich, Germany
Helmuth Adelsberger
3Institute of Neuroscience, Technical University of Munich, Munich, Germany
Jochen Herms
2Center for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany
4DZNE–German Center for Neurodegenerative Diseases, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
Axel Rominger
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany
8Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland
Matthias Brendel
1Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany
5Munich Cluster for Systems Neurology, University of Munich, Munich, Germany

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In this issue
Journal of Nuclear Medicine
Vol. 60, Issue 4
April 1, 2019
Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Apr 2019, 60 (4) 548-554; DOI: 10.2967/jnumed.118.217703
Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice
Carola Focke, Tanja Blume, Benedikt Zott, Yuan Shi, Maximilian Deussing, Finn Peters, Claudio Schmidt, Gernot Kleinberger, Simon Lindner, Franz-Josef Gildehaus, Leonie Beyer, Barbara von Ungern-Sternberg, Peter Bartenstein, Laurence Ozmen, Karlheinz Baumann, Mario M. Dorostkar, Christian Haass, Helmuth Adelsberger, Jochen Herms, Axel Rominger, Matthias Brendel
Journal of Nuclear Medicine Apr 2019, 60 (4) 548-554; DOI: 10.2967/jnumed.118.217703
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