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Research ArticleOncology
Open Access

Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue

Satoshi Kodaira, Yukie Morokoshi, Huizi Keiko Li, Teruaki Konishi, Mieko Kurano and Sumitaka Hasegawa
Journal of Nuclear Medicine April 2019, 60 (4) 497-501; DOI: https://doi.org/10.2967/jnumed.118.216853
Satoshi Kodaira
1Radiation Measurement Research Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
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Yukie Morokoshi
2Radiation and Cancer Biology Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan; and
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Huizi Keiko Li
2Radiation and Cancer Biology Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan; and
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Teruaki Konishi
3Regenerative Therapy Research Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
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Mieko Kurano
1Radiation Measurement Research Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
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Sumitaka Hasegawa
2Radiation and Cancer Biology Team, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan; and
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  • FIGURE 1.
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    FIGURE 1.

    (A) Photomicrograph of sliced tissues; left tissue has specifically localized tumors. (B) Scatterplot of detected α-particle tracks on CR-39. (C) Superposition of tissue image and scatterplot of α-particle tracks. (D) Contour map of α-particle track density in binned positions (Δx, Δy) with 50-μm intervals.

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    FIGURE 2.

    LET spectrum of observed α-particles.

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    FIGURE 3.

    Histogram of observed local absorbed dose for t = 12–43 h, estimated dose corrected by half-life of 211At decay for t = 0–12 h, and estimated total dose for t = 0–43 h. Doses are given in cell scale size (10 μm).

  • FIGURE 4.
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    FIGURE 4.

    Contour map of total local absorbed dose in binned positions (Δx, Δy) with 10-μm intervals.

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Journal of Nuclear Medicine: 60 (4)
Journal of Nuclear Medicine
Vol. 60, Issue 4
April 1, 2019
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Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue
Satoshi Kodaira, Yukie Morokoshi, Huizi Keiko Li, Teruaki Konishi, Mieko Kurano, Sumitaka Hasegawa
Journal of Nuclear Medicine Apr 2019, 60 (4) 497-501; DOI: 10.2967/jnumed.118.216853

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Evidence of Local Concentration of α-Particles from 211At-Labeled Antibodies in Liver Metastasis Tissue
Satoshi Kodaira, Yukie Morokoshi, Huizi Keiko Li, Teruaki Konishi, Mieko Kurano, Sumitaka Hasegawa
Journal of Nuclear Medicine Apr 2019, 60 (4) 497-501; DOI: 10.2967/jnumed.118.216853
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Keywords

  • autoradiography
  • α-particle
  • 211At radionuclide
  • dose distribution
  • microscopy
  • radioimmunotherapy
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