Research ArticleTheranostics
Open Access
Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
Margret Schottelius, Alexander Wurzer, Katharina Wissmiller, Roswitha Beck, Maximilian Koch, Dimitrios Gorpas, Johannes Notni, Tessa Buckle, Matthias N. van Oosterom, Katja Steiger, Vasilis Ntziachristos, Markus Schwaiger, Fijs W.B. van Leeuwen and Hans-Jürgen Wester
Journal of Nuclear Medicine January 2019, 60 (1) 71-78; DOI: https://doi.org/10.2967/jnumed.118.212720
Margret Schottelius
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany
Alexander Wurzer
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany
Katharina Wissmiller
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany
Roswitha Beck
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany
Maximilian Koch
2Chair for Biological Imaging (CBI), Technische Universität München, Munich, Germany, and Institute for Biological and Medical Imaging (IBMI), Helmholtz Centre Munich, Oberschleißheim, Germany
Dimitrios Gorpas
2Chair for Biological Imaging (CBI), Technische Universität München, Munich, Germany, and Institute for Biological and Medical Imaging (IBMI), Helmholtz Centre Munich, Oberschleißheim, Germany
Johannes Notni
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany
Tessa Buckle
3Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Matthias N. van Oosterom
3Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Katja Steiger
4Institute for Pathology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; and
Vasilis Ntziachristos
2Chair for Biological Imaging (CBI), Technische Universität München, Munich, Germany, and Institute for Biological and Medical Imaging (IBMI), Helmholtz Centre Munich, Oberschleißheim, Germany
Markus Schwaiger
5Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
Fijs W.B. van Leeuwen
3Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Hans-Jürgen Wester
1Chair for Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany

Data supplements
Supplemental Data
Files in this Data Supplement:
In this issue
Journal of Nuclear Medicine
Vol. 60, Issue 1
January 1, 2019
Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
Margret Schottelius, Alexander Wurzer, Katharina Wissmiller, Roswitha Beck, Maximilian Koch, Dimitrios Gorpas, Johannes Notni, Tessa Buckle, Matthias N. van Oosterom, Katja Steiger, Vasilis Ntziachristos, Markus Schwaiger, Fijs W.B. van Leeuwen, Hans-Jürgen Wester
Journal of Nuclear Medicine Jan 2019, 60 (1) 71-78; DOI: 10.2967/jnumed.118.212720
Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
Margret Schottelius, Alexander Wurzer, Katharina Wissmiller, Roswitha Beck, Maximilian Koch, Dimitrios Gorpas, Johannes Notni, Tessa Buckle, Matthias N. van Oosterom, Katja Steiger, Vasilis Ntziachristos, Markus Schwaiger, Fijs W.B. van Leeuwen, Hans-Jürgen Wester
Journal of Nuclear Medicine Jan 2019, 60 (1) 71-78; DOI: 10.2967/jnumed.118.212720
Jump to section
Related Articles
Cited By...
- Preclinical Evaluation of 177Lu-rhPSMA-10.1, a Radiopharmaceutical for Prostate Cancer: Biodistribution and Therapeutic Efficacy
- Factors for Differential Outcome Across Cancers in Clinical Molecule-Targeted Fluorescence Imaging
- Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells
- c-MET Receptor-Targeted Fluorescence on the Road to Image-Guided Surgery in Penile Squamous Cell Carcinoma Patients
- Applications of fluorescence-guided surgery across multiple tumor types using a near-infrared labeled EGFR antibody
- Rational Linker Design to Accelerate Excretion and Reduce Background Uptake of Peptidomimetic PSMA-Targeting Hybrid Molecules
- Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies
- Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction
- Prostate-Specific Membrane Antigen-Guided Surgery
- Impact of 18F-PSMA-1007 Uptake in Prostate Cancer Using Different Peptide Concentrations: Preclinical PET/CT Study on Mice