Abstract
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Objectives: To review research applications of mucociliary clearance (MCC) and dual-isotope mucociliary clearance/small molecule absorption (ABS) scans as applied in studies of cystic fibrosis, asthma, and ciliopathies associated with congenital heart disease. A series of research studies performed at our center will be reviewed that includes approximately 50 adult and pediatric subjects. Methods: Aerosol based delivery techniques are utilized. Oral delivery is used for adults and older children and nasal cannula delivery is used for infants. Delivery can also be performed with ventilated subjects and scans can be performed bedside using a portable gamma camera. Technetium 99m sulfur colloid (Tc-SC) is utilized to measure MCC. Indium 111-DTPA (In-DTPA) is added to measure ABS. Serial planar images are used for analysis. (Single window for MCC; three windows for MCC/ABS). Results: MCC measurements have played an important role in therapeutics development for CF. MCC/ABS scans provide a means of assessing changes in liquid absorption in the lungs. ABS is significantly increased in CF airway cell cultures and CF lungs. Techniques for assessing MCC in infants provide a means to better understand congenital clearance abnormalities. Conclusions: Aerosol based techniques for assessing mucociliary clearance and airway liquid absorption can significant augment studies of lung physiology and therapeutic efficacy.
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