Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Susanne Kossatz; Brandon Carney; Christopher Farley; Wolfgang A. Weber; Charles M. Drain; Thomas Reiner

doi:10.2967/jnumed.117.205765

Research ArticleMolecular Imaging

Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Susanne Kossatz, Brandon Carney, Christopher Farley, Wolfgang A. Weber, Charles M. Drain and Thomas Reiner

Journal of Nuclear Medicine August 2018, 59 (8) 1316-1320; DOI: https://doi.org/10.2967/jnumed.117.205765

Susanne Kossatz

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

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Brandon Carney

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

2Hunter College and Graduate Center of the City University of New York, New York, New York

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Christopher Farley

2Hunter College and Graduate Center of the City University of New York, New York, New York

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Wolfgang A. Weber

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

3Department of Radiology, Weill Cornell Medical College, New York, New York; and

4Department of Nuclear Medicine, Technical University Munich, Munich, Germany

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Charles M. Drain

2Hunter College and Graduate Center of the City University of New York, New York, New York

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Thomas Reiner

1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York

3Department of Radiology, Weill Cornell Medical College, New York, New York; and

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Journal of Nuclear Medicine

Vol. 59, Issue 8

August 1, 2018

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Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Susanne Kossatz, Brandon Carney, Christopher Farley, Wolfgang A. Weber, Charles M. Drain, Thomas Reiner

Journal of Nuclear Medicine Aug 2018, 59 (8) 1316-1320; DOI: 10.2967/jnumed.117.205765

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Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib

Susanne Kossatz, Brandon Carney, Christopher Farley, Wolfgang A. Weber, Charles M. Drain, Thomas Reiner

Journal of Nuclear Medicine Aug 2018, 59 (8) 1316-1320; DOI: 10.2967/jnumed.117.205765

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Keywords

PARP1
rucaparib
fluorescence imaging
indole chromophore
drug-target interactions

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